Combination of Intravitreal Injection of Ranibizumab and Photocoagulation for the Treatment of Aggressive Posterior Retinopathy of Prematurity with Vitreous Hemorrhage
Joint Authors
Zhao, Peiquan
Xu, Yu
Kang, Xiaoli
Zhang, Qi
Huang, Qiujing
Lv, Jiao
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
To investigate the efficacy of intravitreal ranibizumab (IVR) combined with laser photocoagulation for aggressive posterior retinopathy of prematurity (AP-ROP) patients with vitreous hemorrhage, we conducted a retrospective observational case series study.
A total of 37 eyes of 20 patients’ medical records were reviewed.
Patients first received IVR (0.25 mg/0.025 mL) and later photocoagulation.
The mean postconceptual age of injection was 34.6 ± 1.4 weeks, and the mean follow-up period was 39.3 ± 8.3 weeks.
During the follow-up, 96.6% eyes had various degree of rapid absorption of vitreous hemorrhage after IVR.
The mean time of received first photocoagulation after IVR was 4.8 ± 2.9 weeks.
Ten (27.0%) eyes received second laser therapy and the mean time of second laser therapy after IVR was 3.2 ± 0.8 weeks.
All eyes exhibited adequate regression of ROP and were stable with attached retina.
Fibrosis membrane was observed in seven eyes (18.9%) and three of them demonstrated mild ectopic macula.
No significant side effects related to IVR were observed.
So IVR could be conducted as primary treatment of AP-ROP associated with vitreous hemorrhage, which can improve the fundus visibility, followed by conventional photocoagulation.
Further randomized controlled trials are necessary to compare the clinical efficacy and safety with conventional interventions.
American Psychological Association (APA)
Xu, Yu& Kang, Xiaoli& Zhang, Qi& Huang, Qiujing& Lv, Jiao& Zhao, Peiquan. 2016. Combination of Intravitreal Injection of Ranibizumab and Photocoagulation for the Treatment of Aggressive Posterior Retinopathy of Prematurity with Vitreous Hemorrhage. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109979
Modern Language Association (MLA)
Xu, Yu…[et al.]. Combination of Intravitreal Injection of Ranibizumab and Photocoagulation for the Treatment of Aggressive Posterior Retinopathy of Prematurity with Vitreous Hemorrhage. Journal of Ophthalmology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1109979
American Medical Association (AMA)
Xu, Yu& Kang, Xiaoli& Zhang, Qi& Huang, Qiujing& Lv, Jiao& Zhao, Peiquan. Combination of Intravitreal Injection of Ranibizumab and Photocoagulation for the Treatment of Aggressive Posterior Retinopathy of Prematurity with Vitreous Hemorrhage. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109979