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Ocular Biocompatibility of Poly-N-Isopropylacrylamide (pNIPAM)
Joint Authors
Lima, Luiz H.
Morales, Yael
Cabral, Thiago
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
To study the safety of intravitreal injections of poly-N-isopropylacrylamide (pNIPAM) tissue adhesive in rabbit eyes.
Methods.
Twelve study rabbits received an intravitreal injection of 0.1 mL 50% pNIPAM in the right eye.
Follow-up examinations included color fundus photography, fundus fluorescein angiography (FA), optical coherence tomography (OCT), and electroretinography (ERG).
Subsequent to the last follow-up assessment, the rabbits were sacrificed and histopathological study on the scleral incision sites was performed.
Results.
All study animals developed mild to moderate levels of inflammatory reaction in the conjunctiva, anterior chamber, and the anterior vitreous during the first month of follow-up.
After this period, the level of the inflammatory reaction progressively decreased and completely disappeared after the third month of follow-up.
The lens and cornea remained clear during the entire follow-up period.
OCT and FA did not show areas of retinal damage or neovascularization.
Histological and ERG studies of eyes injected with pNIPAM demonstrated absence of retinal toxicity.
Conclusion.
Intravitreal injections of pNIPAM were nontoxic in this animal study, and pNIPAM may be safe to be used as a bioadhesive in certain retinal diseases.
American Psychological Association (APA)
Lima, Luiz H.& Morales, Yael& Cabral, Thiago. 2016. Ocular Biocompatibility of Poly-N-Isopropylacrylamide (pNIPAM). Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109992
Modern Language Association (MLA)
Lima, Luiz H.…[et al.]. Ocular Biocompatibility of Poly-N-Isopropylacrylamide (pNIPAM). Journal of Ophthalmology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1109992
American Medical Association (AMA)
Lima, Luiz H.& Morales, Yael& Cabral, Thiago. Ocular Biocompatibility of Poly-N-Isopropylacrylamide (pNIPAM). Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109992