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Evaluation of LATS1 and LATS2 Promoter Methylation with the Risk of Pterygium Formation
Joint Authors
Najafi, Maryam
Kordi-Tamandani, Dor Mohammad
Arish, Mohammad
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
Pterygium is a serious eye problem in countries with high exposure to UV.
However, despite numerous studies, the molecular etiology of pterygium is unclear.
Recent studies have indicated that LATS1 and LATS2 genes are involved in DDR signaling pathways against continuous UV exposure.
Our aim was to evaluate the LATS1 and LATS2 promoter methylation with the risk of pterygium formation.
Methods.
We evaluated the promoter methylation status of LATS1 and LATS2 using methylation-specific PCR technique.
Also, mRNA expression of LATS1 and LATS2 was assessed in 14 cases of pterygium and 14 normal specimens by real-time PCR.
Results.
Promoter methylation of LATS1 and LATS2 was detected significantly between pterygium tissues and normal tissues [LATS1; OR = 4.9; 95% CI: 1.54 to 15.48, P = 0.003 ; LATS2; OR = 7.1; 95% CI: 1.53 to 33.19, P = 0.004 ].
The gene expression analysis showed a statistically significant difference between pterygium tissues and healthy controls for both LATS1 and LATS2 ( P < 0.05 ).
Conclusions.
The data of this study is the first report regarding the effect of promoter methylation of the LATS1 and LATS2 in the pterygium.
To confirm these data, doing further studies in various genetic populations with large sample sizes using advanced molecular techniques is proposed.
American Psychological Association (APA)
Najafi, Maryam& Kordi-Tamandani, Dor Mohammad& Arish, Mohammad. 2016. Evaluation of LATS1 and LATS2 Promoter Methylation with the Risk of Pterygium Formation. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1109995
Modern Language Association (MLA)
Najafi, Maryam…[et al.]. Evaluation of LATS1 and LATS2 Promoter Methylation with the Risk of Pterygium Formation. Journal of Ophthalmology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1109995
American Medical Association (AMA)
Najafi, Maryam& Kordi-Tamandani, Dor Mohammad& Arish, Mohammad. Evaluation of LATS1 and LATS2 Promoter Methylation with the Risk of Pterygium Formation. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1109995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109995