Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System
Joint Authors
He, Zheng
Gurrell, Rachel
Nguyen, Christine T. O.
Charng, Jason
Bui, Bang V.
Fish, Rebecca
Vingrys, Algis J.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
To examine whether retinal electrophysiology is a useful surrogate marker of drug penetrance into the central nervous system (CNS).
Materials and Methods.
Brain and retinal electrophysiology were assessed with full-field visually evoked potentials and electroretinograms in conscious and anaesthetised rats following systemic or local administrations of centrally penetrant (muscimol) or nonpenetrant (isoguvacine) compounds.
Results.
Local injections into the eye/brain bypassed the blood neural barriers and produced changes in retinal/brain responses for both drugs.
In conscious animals, systemic administration of muscimol resulted in retinal and brain biopotential changes, whereas systemic delivery of isoguvacine did not.
General anaesthesia confounded these outcomes.
Conclusions.
Retinal electrophysiology, when recorded in conscious animals, shows promise as a viable biomarker of drug penetration into the CNS.
In contrast, when conducted under anaesthetised conditions confounds can be induced in both cortical and retinal electrophysiological recordings.
American Psychological Association (APA)
Charng, Jason& He, Zheng& Vingrys, Algis J.& Fish, Rebecca& Gurrell, Rachel& Bui, Bang V.…[et al.]. 2016. Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110008
Modern Language Association (MLA)
Charng, Jason…[et al.]. Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System. Journal of Ophthalmology No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1110008
American Medical Association (AMA)
Charng, Jason& He, Zheng& Vingrys, Algis J.& Fish, Rebecca& Gurrell, Rachel& Bui, Bang V.…[et al.]. Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110008
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110008