Comparison of Two Botulinum Neurotoxin A Injection Patterns with or without the Medial Lower Eyelid in the Treatment of Blepharospasm
Joint Authors
Yang, Hui
Luo, Yan
Lu, Lin
Lu, Jing
Zhao, Xiujuan
Ding, Xiaohu
Wang, Zhonghao
Cai, Xiaoyu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of this study was to evaluate the efficacy of two botulinum toxin A (BoNT-A) injection patterns with or without the medial lower eyelid (MLE) in treating benign essential blepharospasm (BEB) and influencing lacrimal drainage.
Two different injection patterns of BoNT-A were randomly applied to 98 eyes of 49 BEB patients: MLE Group received a full injection pattern of 5 sites and non-MLE Group received a MLE waived injection pattern of 4 sites.
Tear breakup time (BUT), Schirmer I test, lagophthalmos height, and lower lid tear meniscus height (TMH) were measured and Jankovic Rating Scale (JRS) was surveyed before injection and at 1 week, 1 month, and 3 months after injection.
The symptom of BEB was relieved in both groups as suggested by JRS scores at all time points after injection, and MLE Group came up with a better JRS score at 3 months.
The increases of Schirmer I test value and TMH in MLE Group were higher than those in non-MLE Group at 1 week after injection.
This study shows that the MLE-involved full injection pattern is a better choice for patients with BEB.
It has longer-lasting effects in relieving BEB symptoms and better efficacy in reducing lacrimal drainage.
Clinical Trials registration number is NCT02327728.
American Psychological Association (APA)
Yang, Hui& Lu, Jing& Zhao, Xiujuan& Ding, Xiaohu& Wang, Zhonghao& Cai, Xiaoyu…[et al.]. 2016. Comparison of Two Botulinum Neurotoxin A Injection Patterns with or without the Medial Lower Eyelid in the Treatment of Blepharospasm. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110015
Modern Language Association (MLA)
Yang, Hui…[et al.]. Comparison of Two Botulinum Neurotoxin A Injection Patterns with or without the Medial Lower Eyelid in the Treatment of Blepharospasm. Journal of Ophthalmology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1110015
American Medical Association (AMA)
Yang, Hui& Lu, Jing& Zhao, Xiujuan& Ding, Xiaohu& Wang, Zhonghao& Cai, Xiaoyu…[et al.]. Comparison of Two Botulinum Neurotoxin A Injection Patterns with or without the Medial Lower Eyelid in the Treatment of Blepharospasm. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110015
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110015