Reliability of Using Retinal Vascular Fractal Dimension as a Biomarker in the Diabetic Retinopathy Detection
Joint Authors
ter Haar Romeny, B. M.
Berendschot, Tos T. J. M.
Huang, Fan
Dashtbozorg, Behdad
Zhang, Jiong
Bekkers, Erik
Abbasi-Sureshjani, Samaneh
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The retinal fractal dimension (FD) is a measure of vasculature branching pattern complexity.
FD has been considered as a potential biomarker for the detection of several diseases like diabetes and hypertension.
However, conflicting findings were found in the reported literature regarding the association between this biomarker and diseases.
In this paper, we examine the stability of the FD measurement with respect to (1) different vessel annotations obtained from human observers, (2) automatic segmentation methods, (3) various regions of interest, (4) accuracy of vessel segmentation methods, and (5) different imaging modalities.
Our results demonstrate that the relative errors for the measurement of FD are significant and FD varies considerably according to the image quality, modality, and the technique used for measuring it.
Automated and semiautomated methods for the measurement of FD are not stable enough, which makes FD a deceptive biomarker in quantitative clinical applications.
American Psychological Association (APA)
Huang, Fan& Dashtbozorg, Behdad& Zhang, Jiong& Bekkers, Erik& Abbasi-Sureshjani, Samaneh& Berendschot, Tos T. J. M.…[et al.]. 2016. Reliability of Using Retinal Vascular Fractal Dimension as a Biomarker in the Diabetic Retinopathy Detection. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1110022
Modern Language Association (MLA)
Huang, Fan…[et al.]. Reliability of Using Retinal Vascular Fractal Dimension as a Biomarker in the Diabetic Retinopathy Detection. Journal of Ophthalmology No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1110022
American Medical Association (AMA)
Huang, Fan& Dashtbozorg, Behdad& Zhang, Jiong& Bekkers, Erik& Abbasi-Sureshjani, Samaneh& Berendschot, Tos T. J. M.…[et al.]. Reliability of Using Retinal Vascular Fractal Dimension as a Biomarker in the Diabetic Retinopathy Detection. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1110022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110022