SENP1-Mediated Desumoylation of DBC1 Inhibits Apoptosis Induced by High Glucose in Bovine Retinal Pericytes
Joint Authors
Xu, Xun
Gu, Qing
Gao, Jian
Chen, Xia
Liu, Xiaoxiao
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Pericyte loss is an early characteristic change in diabetic retinopathy, but its precise molecular mechanisms have not been elucidated.
This study investigated the role of SENP1 in pericyte loss in diabetic retinopathy.
We demonstrated that a high concentration of glucose inhibited the expression of the Sentrin/SUMO-specific protease 1 (SENP1), which resulted in an increase in DBC1 sumoylation in bovine retinal pericytes (BRPCs).
Furthermore, SENP1 overexpression attenuated hyperemia-induced apoptosis of BPRCs, and SENP1 knockdown aggravated this effect.
We also provide evidence that DBC1 sumoylation/desumoylation is involved in the SENP1-regulated apoptosis of BRPCs under high glucose conditions.
Understanding the role of SENP1 in the pathogenesis of high glucose induced pericyte loss could help elucidate important targets for future pharmacological interventions.
American Psychological Association (APA)
Gao, Jian& Chen, Xia& Gu, Qing& Liu, Xiaoxiao& Xu, Xun. 2016. SENP1-Mediated Desumoylation of DBC1 Inhibits Apoptosis Induced by High Glucose in Bovine Retinal Pericytes. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1110026
Modern Language Association (MLA)
Gao, Jian…[et al.]. SENP1-Mediated Desumoylation of DBC1 Inhibits Apoptosis Induced by High Glucose in Bovine Retinal Pericytes. Journal of Ophthalmology No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1110026
American Medical Association (AMA)
Gao, Jian& Chen, Xia& Gu, Qing& Liu, Xiaoxiao& Xu, Xun. SENP1-Mediated Desumoylation of DBC1 Inhibits Apoptosis Induced by High Glucose in Bovine Retinal Pericytes. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1110026
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110026