SENP1-Mediated Desumoylation of DBC1 Inhibits Apoptosis Induced by High Glucose in Bovine Retinal Pericytes

Joint Authors

Xu, Xun
Gu, Qing
Gao, Jian
Chen, Xia
Liu, Xiaoxiao

Source

Journal of Ophthalmology

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-03-27

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Medicine

Abstract EN

Pericyte loss is an early characteristic change in diabetic retinopathy, but its precise molecular mechanisms have not been elucidated.

This study investigated the role of SENP1 in pericyte loss in diabetic retinopathy.

We demonstrated that a high concentration of glucose inhibited the expression of the Sentrin/SUMO-specific protease 1 (SENP1), which resulted in an increase in DBC1 sumoylation in bovine retinal pericytes (BRPCs).

Furthermore, SENP1 overexpression attenuated hyperemia-induced apoptosis of BPRCs, and SENP1 knockdown aggravated this effect.

We also provide evidence that DBC1 sumoylation/desumoylation is involved in the SENP1-regulated apoptosis of BRPCs under high glucose conditions.

Understanding the role of SENP1 in the pathogenesis of high glucose induced pericyte loss could help elucidate important targets for future pharmacological interventions.

American Psychological Association (APA)

Gao, Jian& Chen, Xia& Gu, Qing& Liu, Xiaoxiao& Xu, Xun. 2016. SENP1-Mediated Desumoylation of DBC1 Inhibits Apoptosis Induced by High Glucose in Bovine Retinal Pericytes. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1110026

Modern Language Association (MLA)

Gao, Jian…[et al.]. SENP1-Mediated Desumoylation of DBC1 Inhibits Apoptosis Induced by High Glucose in Bovine Retinal Pericytes. Journal of Ophthalmology No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1110026

American Medical Association (AMA)

Gao, Jian& Chen, Xia& Gu, Qing& Liu, Xiaoxiao& Xu, Xun. SENP1-Mediated Desumoylation of DBC1 Inhibits Apoptosis Induced by High Glucose in Bovine Retinal Pericytes. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1110026

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1110026