![](/images/graphics-bg.png)
Relationship between Altered Platelet Morphological Parameters and Retinopathy in Patients with Type 2 Diabetes Mellitus
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
To investigate whether platelet morphology or function is altered in patients with diabetic retinopathy (DR).
Methods.
This prospective study enrolled 85 healthy controls (HCs) (group 1) and 262 patients with Type 2 diabetes mellitus (T2DM).
Patients were subclassified into three groups according to ocular findings: no DR (group 2; n = 88 ); nonproliferative DR (group 3; n = 88 ), and proliferative DR (group 4; n = 86 ).
Mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (PLCR), plateletcrit (PCT) values, and platelet count were measured in the studied groups.
Results.
MPV, PDW, and PLCR levels were significantly altered in groups 2–4 compared with HCs ( p < 0.05 , p < 0.05 , p < 0.05 ).
Compared with group 2, both DR groups had higher MPV and PDW levels, with a significant difference between groups 2 and 4 for both MPV ( p = 0.036 ) and PDW ( p = 0.006 ).
PLCR correlated with retinopathy stage, but no significant difference was found between the DR groups.
Platelet count and PCT values were not significantly different between the groups ( p > 0.05 ).
Conclusion.
Our findings suggest an association between mean platelet indices (MPI) (i.e., MPV, PDW, and PLCR) and DR stage.
Therefore, MPI could be a beneficial prognostic marker of DR in patients with T2DM.
American Psychological Association (APA)
Yilmaz, Tolga& Yilmaz, Ahu. 2016. Relationship between Altered Platelet Morphological Parameters and Retinopathy in Patients with Type 2 Diabetes Mellitus. Journal of Ophthalmology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1110117
Modern Language Association (MLA)
Yilmaz, Tolga& Yilmaz, Ahu. Relationship between Altered Platelet Morphological Parameters and Retinopathy in Patients with Type 2 Diabetes Mellitus. Journal of Ophthalmology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1110117
American Medical Association (AMA)
Yilmaz, Tolga& Yilmaz, Ahu. Relationship between Altered Platelet Morphological Parameters and Retinopathy in Patients with Type 2 Diabetes Mellitus. Journal of Ophthalmology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1110117
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110117