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Effect of Denosumab on Bone Mineral Density and Markers of Bone Turnover among Postmenopausal Women with Osteoporosis
Joint Authors
Sánchez, A.
Brun, L. R.
Salerni, H.
González, D.
Bagur, A.
Oliveri, B.
Zanchetta, M. B.
Farías, V.
Maffei, L.
Premrou, V.
Mansur, J. L.
Larroudé, M. S.
Sarli, M. A.
Rey, P.
Ulla, M. R.
Pavlove, M. M.
Karlsbrum, S.
Brance, M. L.
Costanzo, Pablo R.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of this study was to evaluate the effect of denosumab (Dmab) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment.
Additionally, the effect of Dmab in bisphosphonate-naïve patients (BP-naïve) compared to patients previously treated with bisphosphonates (BP-prior) was analyzed.
This retrospective study included 425 postmenopausal women treated with Dmab for 1 year in clinical practice conditions in specialized centers from Argentina.
Participants were also divided according to previous bisphosphonate treatment into BP-naïve and BP-prior.
A control group of patients treated with BP not switched to Dmab matched by sex, age, and body mass index was used.
Data are expressed as mean ± SEM.
After 1 year of treatment with Dmab the bone formation markers total alkaline phosphatase and osteocalcin were significantly decreased (23.36% and 43.97%, resp.), as was the bone resorption marker s-CTX (69.61%).
Significant increases in BMD were observed at the lumbar spine, femoral neck, and total hip without differences between BP-naïve and BP-prior.
A better BMD response was found in BP-prior group compared with BP treated patients not switched to Dmab.
Conclusion.
Dmab treatment increased BMD and decreased bone turnover markers in the whole group, with similar response in BP-naïve and BP-prior patients.
A better BMD response in BP-prior patients versus BP treated patients not switched to Dmab was observed.
American Psychological Association (APA)
Sánchez, A.& Brun, L. R.& Salerni, H.& Costanzo, Pablo R.& González, D.& Bagur, A.…[et al.]. 2016. Effect of Denosumab on Bone Mineral Density and Markers of Bone Turnover among Postmenopausal Women with Osteoporosis. Journal of Osteoporosis،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110169
Modern Language Association (MLA)
Sánchez, A.…[et al.]. Effect of Denosumab on Bone Mineral Density and Markers of Bone Turnover among Postmenopausal Women with Osteoporosis. Journal of Osteoporosis No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1110169
American Medical Association (AMA)
Sánchez, A.& Brun, L. R.& Salerni, H.& Costanzo, Pablo R.& González, D.& Bagur, A.…[et al.]. Effect of Denosumab on Bone Mineral Density and Markers of Bone Turnover among Postmenopausal Women with Osteoporosis. Journal of Osteoporosis. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110169