Multidrug Resistant CTX-M-Producing Escherichia coli: A Growing Threat among HIV Patients in India
Joint Authors
Padmavathy, Kesavaram
Padma, Krishnan
Rajasekaran, Sikhamani
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Extended Spectrum β-Lactamases (ESBLs) confer resistance to third-generation cephalosporins and CTX-M types have emerged as the most prominent ESBLs worldwide.
This study was designed to determine the prevalence of CTX-M positive ESBL-producing urinary E.
coli isolates from HIV patients and to establish the association of multidrug resistance, phylogeny, and virulence profile with CTX-M production.
A total of 57 ESBL producers identified among 76 E.
coli strains isolated from HIV patients from South India were screened for b l a C T X - M , AmpC production, multidrug resistance, and nine virulence associated genes (VAGs), fimH, pap, afa/dra, sfa/foc, iutA, fyuA, iroN, usp, and kpsMII.
The majority (70.2%) of the ESBL producers harbored b l a C T X - M and were AmpC coproducers.
Among the CTX-M producers, 47.5% were found to be UPEC, 10% harbored as many as 7 VAGs, and 45% possessed kpsMII.
Multidrug resistance (CIPRSXTRGENR) was significantly more common among the CTX-M producers compared to the nonproducers (70% versus 41.2%).
However, 71.4% of the multidrug resistant CTX-M producers exhibited susceptibility to nitrofurantoin thereby making it an effective alternative to cephalosporins/fluoroquinolones.
The emergence of CTX-M-producing highly virulent, multidrug resistant uropathogenic E.
coli is of significant public health concern in countries like India with a high burden of HIV/AIDS.
American Psychological Association (APA)
Padmavathy, Kesavaram& Padma, Krishnan& Rajasekaran, Sikhamani. 2016. Multidrug Resistant CTX-M-Producing Escherichia coli: A Growing Threat among HIV Patients in India. Journal of Pathogens،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110207
Modern Language Association (MLA)
Padmavathy, Kesavaram…[et al.]. Multidrug Resistant CTX-M-Producing Escherichia coli: A Growing Threat among HIV Patients in India. Journal of Pathogens No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1110207
American Medical Association (AMA)
Padmavathy, Kesavaram& Padma, Krishnan& Rajasekaran, Sikhamani. Multidrug Resistant CTX-M-Producing Escherichia coli: A Growing Threat among HIV Patients in India. Journal of Pathogens. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110207
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110207