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Probing into the Interaction of Nicotine and Bovine Submaxillary Mucin: NMR, Fluorescence, and FTIR Approaches
Joint Authors
Liao, Xiaoxiang
Yuan, Dalin
Tang, Jianguo
Yang, Hongqin
Liang, Bing
Cheng, Qiang
Li, Hui
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nicotine, the important component of cigarette products, may have an impact on the oral environment after inhalation.
The research of interaction between nicotine and bovine submaxillary mucin (BSM) contributes to understand the binding mechanism of nicotine and BSM, and the effects of nicotine on the structure and function of the mucin.
NMR data demonstrated that the interaction between nicotine and BSM did exist, and it was pyrrolidyl ring of nicotine playing the major role in the binding.
The quenching mechanisms of nicotine and BSM in different pH were different: for acidic environment, the quenching was dynamic; while it became static in the alkaline circumstance.
Synchronous fluorescence spectra indicated that nicotine had effect on the microenvironment of the Trp rather than Tyr residue.
Meanwhile, the impact of nicotine on the conformation of BSM was also confirmed by 3D fluorescence and FTIR spectra.
American Psychological Association (APA)
Liao, Xiaoxiang& Yuan, Dalin& Tang, Jianguo& Yang, Hongqin& Liang, Bing& Cheng, Qiang…[et al.]. 2016. Probing into the Interaction of Nicotine and Bovine Submaxillary Mucin: NMR, Fluorescence, and FTIR Approaches. Journal of Spectroscopy،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110815
Modern Language Association (MLA)
Liao, Xiaoxiang…[et al.]. Probing into the Interaction of Nicotine and Bovine Submaxillary Mucin: NMR, Fluorescence, and FTIR Approaches. Journal of Spectroscopy No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1110815
American Medical Association (AMA)
Liao, Xiaoxiang& Yuan, Dalin& Tang, Jianguo& Yang, Hongqin& Liang, Bing& Cheng, Qiang…[et al.]. Probing into the Interaction of Nicotine and Bovine Submaxillary Mucin: NMR, Fluorescence, and FTIR Approaches. Journal of Spectroscopy. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110815
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110815