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A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine
Joint Authors
Clewell, Amy
Hirka, Gábor
Glávits, Róbert
Palmer, Philip A.
Endres, John R.
Murbach, Timothy S.
Marx, Tennille
Pasics Szakonyiné, Ilona
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-22
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
A 90-day repeated-dose oral toxicological evaluation was conducted according to GLP and OECD guidelines on the methylurate purine alkaloid theacrine, which is found naturally in certain plants.
Four groups of Hsd.Brl.Han Wistar rats (ten/sex/group) were administered theacrine by gavage doses of 0 (vehicle only), 180, 300, and 375 mg/kg bw/day.
Two females and one male in the 300 and 375 mg/kg bw/day groups, respectively, died during the study.
Histological examination revealed centrilobular hepatocellular necrosis as the probable cause of death.
In 375 mg/kg bw/day males, slight reductions in body weight development, food consumption, and feed efficiency, decreased weight of the testes and epididymides and decreased intensity of spermatogenesis in the testes, lack or decreased amount of mature spermatozoa in the epididymides, and decreased amount of prostatic secretions were detected at the end of the three months.
At 300 mg/kg bw/day, slight decreases in the weights of the testes and epididymides, along with decreased intensity of spermatogenesis in the testes, and lack or decreased amount of mature spermatozoa in the epididymides were detected in male animals.
The NOAEL was considered to be 180 mg/kg bw/day, as at this dose there were no toxicologically relevant treatment-related findings in male or female animals.
American Psychological Association (APA)
Clewell, Amy& Hirka, Gábor& Glávits, Róbert& Palmer, Philip A.& Endres, John R.& Murbach, Timothy S.…[et al.]. 2016. A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine. Journal of Toxicology،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1110828
Modern Language Association (MLA)
Clewell, Amy…[et al.]. A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine. Journal of Toxicology No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1110828
American Medical Association (AMA)
Clewell, Amy& Hirka, Gábor& Glávits, Róbert& Palmer, Philip A.& Endres, John R.& Murbach, Timothy S.…[et al.]. A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine. Journal of Toxicology. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1110828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110828