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Comparisons of Curative Effects of Chlorophyll from Sauropus androgynus (L) Merr Leaf Extract and Cu-Chlorophyllin on Sodium Nitrate-Induced Oxidative Stress in Rats
Joint Authors
Suparmi, Suparmi
Fasitasari, Minidian
Martosupono, Martanto
Mangimbulude, Jubhar Christian
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Sodium nitrate (NaNO2) widely used as food additive for coloring and preserving meat has been reported to induce oxidative stress and cause histopathologic changes, nitrosative tissue damage, and lipid peroxidation in liver and kidney.
Therefore, the present study compared the curative effect of chlorophyll from Sauropus androgynus (L) Merr and Cu-chlorophyllin as antioxidant in NaNO2-induced female Wistar rats based on haematological, serum biochemical, and histological evaluation.
Thirty male Wistar rats were randomly assigned into six groups of five rats each.
NaNO2 were given at a subacute dose of 50 mg/kg bw intraperitoneally for 10 days.
Chlorophyll from S.
androgynus and Cu-chlorophyllin from K-Liquid™ were given in the following 14 days at the two doses: 0,016 mg/mL and 0.008 mg/mL.
NaNO2 exposure resulted in significant reductions (p<0.05) in values of packed cell volume (PCV), haemoglobin (Hb) concentration and red blood cell (RBC) count, transferrin, and ferritin and elevation in malondialdehyde (MDA) level and schistocytes percentage with insignificant reductions in serum albumin and transferrin levels.
Histology of kidney and liver were changed insignificantly (p>0.05) to normal values.
Chlorophyll from S.
androgynus and Cu-chlorophyllin possess antioxidant potentials to protect against toxicities induced by sodium nitrate.
American Psychological Association (APA)
Suparmi, Suparmi& Fasitasari, Minidian& Martosupono, Martanto& Mangimbulude, Jubhar Christian. 2016. Comparisons of Curative Effects of Chlorophyll from Sauropus androgynus (L) Merr Leaf Extract and Cu-Chlorophyllin on Sodium Nitrate-Induced Oxidative Stress in Rats. Journal of Toxicology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1110835
Modern Language Association (MLA)
Suparmi, Suparmi…[et al.]. Comparisons of Curative Effects of Chlorophyll from Sauropus androgynus (L) Merr Leaf Extract and Cu-Chlorophyllin on Sodium Nitrate-Induced Oxidative Stress in Rats. Journal of Toxicology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1110835
American Medical Association (AMA)
Suparmi, Suparmi& Fasitasari, Minidian& Martosupono, Martanto& Mangimbulude, Jubhar Christian. Comparisons of Curative Effects of Chlorophyll from Sauropus androgynus (L) Merr Leaf Extract and Cu-Chlorophyllin on Sodium Nitrate-Induced Oxidative Stress in Rats. Journal of Toxicology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1110835
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110835