The Effect of Aqueous Extract of Cinnamon on the Metabolome of Plasmodium falciparum Using 1HNMR Spectroscopy
Joint Authors
Arjmand, Mohammad
Sadeghi, Sedigheh
Parvazi, Shirin
Azadi, Mehri
Mohammadi, Maryam
Vahabi, Farideh
Sadeghzadeh, Somye
Zamani, Zahra
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Malaria is responsible for estimated 584,000 deaths in 2013.
Researchers are working on new drugs and medicinal herbs due to drug resistance that is a major problem facing them; the search is on for new medicinal herbs.
Cinnamon is the bark of a tree with reported antiparasitic effects.
Metabonomics is the simultaneous study of all the metabolites in biological fluids, cells, and tissues detected by high throughput technology.
It was decided to determine the mechanism of the effect of aqueous extract of cinnamon on the metabolome of Plasmodium falciparum in vitro using 1HNMR spectroscopy.
Prepared aqueous extract of cinnamon was added to a culture of Plasmodium falciparum 3D7 and its 50% inhibitory concentration determined, and, after collection, their metabolites were extracted and 1HNMR spectroscopy by NOESY method was done.
The spectra were analyzed by chemometric methods.
The differentiating metabolites were identified using Human Metabolome Database and the metabolic cycles identified by Metaboanalyst.
50% inhibitory concentration of cinnamon on Plasmodium falciparum was 1.25 mg/mL with p<0.001.
The metabolites were identified as succinic acid, glutathione, L-aspartic acid, beta-alanine, and 2-methylbutyryl glycine.
The main metabolic cycles detected were alanine and aspartame and glutamate pathway and pantothenate and coenzyme A biosynthesis and lysine biosynthesis and glutathione metabolism, which are all important as drug targets.
American Psychological Association (APA)
Parvazi, Shirin& Sadeghi, Sedigheh& Azadi, Mehri& Mohammadi, Maryam& Arjmand, Mohammad& Vahabi, Farideh…[et al.]. 2016. The Effect of Aqueous Extract of Cinnamon on the Metabolome of Plasmodium falciparum Using 1HNMR Spectroscopy. Journal of Tropical Medicine،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1110847
Modern Language Association (MLA)
Parvazi, Shirin…[et al.]. The Effect of Aqueous Extract of Cinnamon on the Metabolome of Plasmodium falciparum Using 1HNMR Spectroscopy. Journal of Tropical Medicine No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1110847
American Medical Association (AMA)
Parvazi, Shirin& Sadeghi, Sedigheh& Azadi, Mehri& Mohammadi, Maryam& Arjmand, Mohammad& Vahabi, Farideh…[et al.]. The Effect of Aqueous Extract of Cinnamon on the Metabolome of Plasmodium falciparum Using 1HNMR Spectroscopy. Journal of Tropical Medicine. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1110847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110847