Morphological Diversity of Pretibial Myxedema and Its Mechanism of Evolving Process and Outcome: A Retrospective Study of 216 Cases
Joint Authors
Lan, Changgui
Wang, Yi
Zeng, Xia
Zhao, Jing
Zou, Xiaoxi
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-25
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Background.
Pretibial myxedema (PTM) is a rare dermopathy.
The morphologic features and mechanism of its evolving process are not reported in large case series.
Methods.
216 cases with PTM were retrospectively reviewed to analyze demographics, history, lesional morphology and its evolving process, histopathology and immunohistochemistry, serum TRAb levels, treatment, and outcome.
Results.
First appearing lesions evolved into 6 variants that were correlated with serum TRAb levels.
Subvariants were caused by different kinds and frequencies of local trauma.
The evolving process could be classified into 4 stages that were correlated with serum TRAb levels and perivascular infiltration of CD8+ and CD4+ lymphocytes.
Serum TRAb levels at remission and in nonrecurred cases became lower than those before therapy and in recurred cases, respectively, but increased when PTM relapsed.
TRAb level in nodule variant went down invariably with the extension of course and its autoimmune activity had a trend to stop but in other 5 variants TRAb levels fluctuated.
Their autoimmune activities had no trends to stop and clinically worsen through intermittent repeats of active and stable stages.
Conclusions.
In the chronic course of PTM, nodule variant is self-limited and other 5 variants are not self-limited.
PTM needed early treatment to avoid severe variants.
American Psychological Association (APA)
Lan, Changgui& Wang, Yi& Zeng, Xia& Zhao, Jing& Zou, Xiaoxi. 2016. Morphological Diversity of Pretibial Myxedema and Its Mechanism of Evolving Process and Outcome: A Retrospective Study of 216 Cases. Journal of Thyroid Research،Vol. 2016, no. 2016, pp.1-23.
https://search.emarefa.net/detail/BIM-1110875
Modern Language Association (MLA)
Lan, Changgui…[et al.]. Morphological Diversity of Pretibial Myxedema and Its Mechanism of Evolving Process and Outcome: A Retrospective Study of 216 Cases. Journal of Thyroid Research No. 2016 (2016), pp.1-23.
https://search.emarefa.net/detail/BIM-1110875
American Medical Association (AMA)
Lan, Changgui& Wang, Yi& Zeng, Xia& Zhao, Jing& Zou, Xiaoxi. Morphological Diversity of Pretibial Myxedema and Its Mechanism of Evolving Process and Outcome: A Retrospective Study of 216 Cases. Journal of Thyroid Research. 2016. Vol. 2016, no. 2016, pp.1-23.
https://search.emarefa.net/detail/BIM-1110875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110875