![](/images/graphics-bg.png)
Quercetin-Induced Cell Death in Human Papillary Thyroid Cancer (B-CPAP) Cells
Joint Authors
Mutlu Altundağ, Ergül
Kasacı, Tolga
Yılmaz, Ayşe Mine
Karademir, Betül
Koçtürk, Semra
Taga, Yavuz
Yalçın, A. Süha
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
In this study, we have investigated the antiproliferative effect of quercetin on human papillary thyroid cancer cells and determined the apoptotic mechanisms underlying its actions.
We have used different concentrations of quercetin to induce apoptosis and measured cell viability.
Apoptosis and cell cycle analysis was determined by flow cytometry using Annexin V and propidium iodide.
Finally, we have measured changes in caspase-3 and cleaved poly(ADP-ribose) polymerase (PARP) protein expression levels as hallmarks of apoptosis and Hsp90 protein expression level as a marker of proteasome activity in treated and control cells.
Quercetin treatment of human papillary thyroid cancer cells resulted in decreased cell proliferation and increased rate of apoptosis by caspase activation.
Furthermore, it was demonstrated that quercetin induces cancer cell apoptosis by downregulating the levels of Hsp90.
In conclusion, we have shown that quercetin induces downregulation of Hsp90 expression that may be involved in the decrease of chymotrypsin-like proteasome activity which, in order, induces inhibition of growth and causes cell death in thyroid cancer cells.
Thus, quercetin appears to be a promising candidate drug for Hsp90 downregulation and apoptosis of thyroid cancer cells.
American Psychological Association (APA)
Mutlu Altundağ, Ergül& Kasacı, Tolga& Yılmaz, Ayşe Mine& Karademir, Betül& Koçtürk, Semra& Taga, Yavuz…[et al.]. 2016. Quercetin-Induced Cell Death in Human Papillary Thyroid Cancer (B-CPAP) Cells. Journal of Thyroid Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110887
Modern Language Association (MLA)
Mutlu Altundağ, Ergül…[et al.]. Quercetin-Induced Cell Death in Human Papillary Thyroid Cancer (B-CPAP) Cells. Journal of Thyroid Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1110887
American Medical Association (AMA)
Mutlu Altundağ, Ergül& Kasacı, Tolga& Yılmaz, Ayşe Mine& Karademir, Betül& Koçtürk, Semra& Taga, Yavuz…[et al.]. Quercetin-Induced Cell Death in Human Papillary Thyroid Cancer (B-CPAP) Cells. Journal of Thyroid Research. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110887
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110887