Incidence, Characteristics, and Prognosis of Incidentally Discovered Hepatocellular Carcinoma after Liver Transplantation
Joint Authors
Meeberg, Glenda A.
Kneteman, Norman M.
El Moghazy, Walid
Kashkoush, Samy
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
We aimed to assess incidentally discovered hepatocellular carcinoma (iHCC) over time and to compare outcome to preoperatively diagnosed hepatocellular carcinoma (pdHCC) and nontumor liver transplants.
Methods.
We studied adults transplanted with a follow-up of at least one year.
Patients were divided into 3 groups according to diagnosis of hepatocellular carcinoma.
Results.
Between 1990 and 2010, 887 adults were transplanted.
Among them, 121 patients (13.6%) had pdHCC and 32 patients (3.6%) had iHCC; frequency of iHCC decreased markedly over years, in parallel with significant increase in pdHCC.
Between 1990 and 1995, 120 patients had liver transplants, 4 (3.3%) of them had iHCC, and only 3 (2.5%) had pdHCC, while in the last 5 years, 263 patients were transplanted, 7 (0.03%) of them had iHCC, and 66 (25.1%) had pdHCC ( P < 0.001 ).
There was no significant difference between groups regarding patient survival; 5-year survival was 74%, 75.5%, and 77.3% in iHCC, pdHCC, and non-HCC groups, respectively ( P = 0.702 ).
Patients with iHCC had no recurrences after transplant, while pdHCC patients experienced 17 recurrences (15.3%) ( P = 0.016 ).
Conclusions.
iHCC has significantly decreased despite steady increase in number of transplants for hepatocellular carcinoma.
Patients with iHCC had excellent outcomes with no tumor recurrence and survival comparable to pdHCC.
American Psychological Association (APA)
El Moghazy, Walid& Kashkoush, Samy& Meeberg, Glenda A.& Kneteman, Norman M.. 2016. Incidence, Characteristics, and Prognosis of Incidentally Discovered Hepatocellular Carcinoma after Liver Transplantation. Journal of Transplantation،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110889
Modern Language Association (MLA)
El Moghazy, Walid…[et al.]. Incidence, Characteristics, and Prognosis of Incidentally Discovered Hepatocellular Carcinoma after Liver Transplantation. Journal of Transplantation No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1110889
American Medical Association (AMA)
El Moghazy, Walid& Kashkoush, Samy& Meeberg, Glenda A.& Kneteman, Norman M.. Incidence, Characteristics, and Prognosis of Incidentally Discovered Hepatocellular Carcinoma after Liver Transplantation. Journal of Transplantation. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110889