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C1Q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies: High Specificity but Low Sensitivity When Predicting Flow Crossmatch
Joint Authors
Granados, Julio
Arreola-Guerra, José M.
Castelán, Natalia
de Santiago, Adrián
Arvizu, Adriana
Gonzalez-Tableros, Norma
López, Mayra
Salcedo, Isaac
Alberu, Josefina
Vilatoba, M.
Morales-Buenrostro, L. E.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of the present study was to describe the association of positive flow cross match (FXM) and C1q-SAB.
Methods.
In this observational, cross-sectional, and comparative study, patients included had negative AHG-CDC-XM and donor specific antibodies (DSA) and were tested with FXM.
All pretransplant sera were tested with C1q-SAB assay.
Results.
A total of 50 donor/recipient evaluations were conducted; half of them had at least one C1q+ Ab ( n = 26 , 52%).
Ten patients (20.0%) had DSA C1q+ Ab.
Twenty-five (50%) FXMs were positive.
Factors associated with a positive FXM were the presence of C1q+ Ab (DSA C1q+ Ab: OR 27, 2.80–259.56, P = 0 .
004 , and no DSA C1q+ Ab: OR 5, 1.27–19.68, P = 0 .
021 ) and the DSA LABScreen-SAB MFI (OR 1.26, 95% CI 1.06–1.49, P = 0 .
007 ).
The cutoff point of immunodominant LABScreen SAB DSA-MFI with the greatest sensitivity and specificity to predict FXM was 2,300 (sensitivity: 72% and specificity: 75%).
For FXM prediction, DSA C1q+ Ab was the most specific (95.8%, 85–100) and the combination of DSA-MFI > 2,300 and C1q+ Ab was the most sensitive (92.0%, 79.3–100).
Conclusions.
C1q+ Ab and LABScreen SAB DSA-MFI were significantly associated with FXM.
DSA C1q+ Ab was highly specific but with low sensitivity.
American Psychological Association (APA)
Arreola-Guerra, José M.& Castelán, Natalia& de Santiago, Adrián& Arvizu, Adriana& Gonzalez-Tableros, Norma& López, Mayra…[et al.]. 2016. C1Q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies: High Specificity but Low Sensitivity When Predicting Flow Crossmatch. Journal of Transplantation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1110890
Modern Language Association (MLA)
Arreola-Guerra, José M.…[et al.]. C1Q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies: High Specificity but Low Sensitivity When Predicting Flow Crossmatch. Journal of Transplantation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1110890
American Medical Association (AMA)
Arreola-Guerra, José M.& Castelán, Natalia& de Santiago, Adrián& Arvizu, Adriana& Gonzalez-Tableros, Norma& López, Mayra…[et al.]. C1Q Assay Results in Complement-Dependent Cytotoxicity Crossmatch Negative Renal Transplant Candidates with Donor-Specific Antibodies: High Specificity but Low Sensitivity When Predicting Flow Crossmatch. Journal of Transplantation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1110890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110890