Liver Transplantation for Hepatocellular Carcinoma: A Single Center Resume Overlooking Four Decades of Experience
Joint Authors
Lehner, Frank
Manns, Michael P.
Klempnauer, Juergen
Schrem, Harald
Bektas, Hüseyin
Ramackers, W.
Peters, Rickmer
Ringe, Bastian P.
Güner, Zeynep
Emmanouilidis, Nikos
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-10
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Background.
This is a single center oncological resume overlooking four decades of experience with liver transplantation (LT) for hepatocellular carcinoma (HCC).
Methods.
All 319 LT for HCC that were performed between 1975 and 2011 were included.
Predictors for HCC recurrence (HCCR) and survival were identified by Cox regression, Kaplan-Meier analysis, Log Rank, and χ2-tests where appropriate.
Results.
HCCR was the single strongest hazard for survival (expB=10.156).
Hazards for HCCR were tumor staging beyond the histologic MILAN (expB=3.645), bilateral tumor spreading (expB=14.505), tumor grading beyond G2 (expB=8.668), and vascular infiltration of small or large vessels (expB=11.612, expB=18.324, resp.).
Grading beyond G2 (expB=10.498) as well as small and large vascular infiltrations (expB=13.337, expB=16.737, resp.) was associated with higher hazard ratios for long-term survival as compared to liver transplantation beyond histological MILAN (expB=4.533).
Tumor dedifferentiation significantly correlated with vascular infiltration (χ2p=0.006) and intrahepatic tumor spreading (χ2p=0.016).
Conclusion.
LT enables survival from HCC.
HCC dedifferentiation is associated with vascular infiltration and intrahepatic tumor spreading and is a strong hazard for HCCR and survival.
Pretransplant tumor staging should include grading by biopsy, because grading is a reliable and easily accessible predictor of HCCR and survival.
Detection of dedifferentiation should speed up the allocation process.
American Psychological Association (APA)
Emmanouilidis, Nikos& Peters, Rickmer& Ringe, Bastian P.& Güner, Zeynep& Ramackers, W.& Bektas, Hüseyin…[et al.]. 2016. Liver Transplantation for Hepatocellular Carcinoma: A Single Center Resume Overlooking Four Decades of Experience. Journal of Transplantation،Vol. 2016, no. 2016, pp.1-22.
https://search.emarefa.net/detail/BIM-1110900
Modern Language Association (MLA)
Emmanouilidis, Nikos…[et al.]. Liver Transplantation for Hepatocellular Carcinoma: A Single Center Resume Overlooking Four Decades of Experience. Journal of Transplantation No. 2016 (2016), pp.1-22.
https://search.emarefa.net/detail/BIM-1110900
American Medical Association (AMA)
Emmanouilidis, Nikos& Peters, Rickmer& Ringe, Bastian P.& Güner, Zeynep& Ramackers, W.& Bektas, Hüseyin…[et al.]. Liver Transplantation for Hepatocellular Carcinoma: A Single Center Resume Overlooking Four Decades of Experience. Journal of Transplantation. 2016. Vol. 2016, no. 2016, pp.1-22.
https://search.emarefa.net/detail/BIM-1110900
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110900