Impact of Recipient and Donor Obesity Match on the Outcomes of Liver Transplantation: All Matches Are Not Perfect
Joint Authors
Beal, Eliza W.
Mumtaz, Khalid
Tumin, Dmitry
Conteh, Lanla F.
Hanje, A. James
Michaels, Anthony J.
Hayes, Don
Black, Sylvester M.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
There is a paucity of literature examining recipient-donor obesity matching on liver transplantation outcomes.
The United Network for Organ Sharing database was queried for first-time recipients of liver transplant whose age was ≥18 between January 2003 and September 2013.
Outcomes including patient and graft survival at 30 days, 1 year, and 5 years and overall, liver retransplantation, and length of stay were compared between nonobese recipients receiving a graft from nonobese donors and obese recipient-obese donor, obese recipient-nonobese donor, and nonobese recipient-obese donor pairs.
51,556 LT recipients were identified, including 34,217 (66%) nonobese and 17,339 (34%) obese recipients.
The proportions of patients receiving an allograft from an obese donor were 24% and 29%, respectively, among nonobese and obese recipients.
Graft loss (HR: 1.27; 95% CI: 1.09–1.46; p = 0.002 ) and mortality (HR: 1.38; 95% CI: 1.16–1.65; p < 0.001 ) at 30 days were increased in the obese recipient-obese donor pair.
However, 1-year graft (HR: 0.83; 95% CI: 0.74–0.93; p = 0.002 ) and patient (HR: 0.84; 95% CI: 0.74–0.95; p = 0.007 ) survival and overall patient (HR: 0.93; 95% CI: 0.86–1.00; p = 0.042 ) survival were favorable.
There is evidence of recipient and donor obesity disadvantage early, but survival curves demonstrate improved long-term outcomes.
It is important to consider obesity in the donor-recipient match.
American Psychological Association (APA)
Beal, Eliza W.& Tumin, Dmitry& Conteh, Lanla F.& Hanje, A. James& Michaels, Anthony J.& Hayes, Don…[et al.]. 2016. Impact of Recipient and Donor Obesity Match on the Outcomes of Liver Transplantation: All Matches Are Not Perfect. Journal of Transplantation،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110903
Modern Language Association (MLA)
Beal, Eliza W.…[et al.]. Impact of Recipient and Donor Obesity Match on the Outcomes of Liver Transplantation: All Matches Are Not Perfect. Journal of Transplantation No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1110903
American Medical Association (AMA)
Beal, Eliza W.& Tumin, Dmitry& Conteh, Lanla F.& Hanje, A. James& Michaels, Anthony J.& Hayes, Don…[et al.]. Impact of Recipient and Donor Obesity Match on the Outcomes of Liver Transplantation: All Matches Are Not Perfect. Journal of Transplantation. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110903