The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis withwithout Löfgren’s Syndrome
Joint Authors
Petrek, Martin
Novosadova, Eva
Chabronova, Alzbeta
Kolek, Vitezslav
Navratilova, Zdenka
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Purpose.
Pulmonary sarcoidosis is associated with dysregulated expression of intracellular miRNAs.
There is however only little information on extracellular miRNAs and their association with the disease course in sarcoidosis.
We therefore assessed serum miRNAs in sarcoidosis classified according to the presence of Löfgren’s syndrome (LS) as a hallmark of good prognosis in contrast to more advanced disease course.
Methods.
RT-PCR was used to assess 35 miRNAs in 13 healthy controls and 24 sarcoidosis patients (12 with X-ray (CXR) stage ≤ 1 and LS and 12 with insidious onset and CXR stage ≥ 3).
Results.
Compared to controls, we consistently observed dysregulated expressions of miR-146, miR-16, miR-425-5p, and miR-93-5p in both sarcoidosis groups irrespective of disease course.
Specifically, patients without LS had dysregulated expressions of miR-150-5p, miR-1, and miR-212 compared to controls.
Patients with LS had dysregulated expressions of miR-21-5p and miR-340-5p compared to controls.
Bioinformatics predicted consistently “Pathways in cancer” to be modulated by both altered profiles in patients with/without LS.
Three miRNAs (miR-21-5p, miR-340-5p, and miR-212-3p) differed between our patients with LS and those without LS; their cumulative effect may modulate “TGF-β signalling pathway.” Conclusions.
Further study should focus on possible applications of serum miRNAs for diagnostics follow-up and for prognosis.
American Psychological Association (APA)
Novosadova, Eva& Chabronova, Alzbeta& Kolek, Vitezslav& Petrek, Martin& Navratilova, Zdenka. 2016. The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis withwithout Löfgren’s Syndrome. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110923
Modern Language Association (MLA)
Novosadova, Eva…[et al.]. The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis withwithout Löfgren’s Syndrome. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1110923
American Medical Association (AMA)
Novosadova, Eva& Chabronova, Alzbeta& Kolek, Vitezslav& Petrek, Martin& Navratilova, Zdenka. The Serum Expression of Selected miRNAs in Pulmonary Sarcoidosis withwithout Löfgren’s Syndrome. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110923