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Irbesartan Ameliorates Diabetic Nephropathy by Suppressing the RANKL-RANK-NF-κB Pathway in Type 2 Diabetic dbdb Mice
Joint Authors
Niu, Hong-xin
Chen, Xiao-wen
Du, Xiao-yan
Long, Hai-bo
Wang, Yu-Xian
Wang, Jian-Cheng
Liu, Wen-Ting
Chen, Wen-Jing
Li, Hong-Yu
Peng, Fen-Fen
Xu, Zhao-Zhong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The receptor activator of NF-κB ligand (RANKL) and its receptor RANK are overexpressed in focal segmental glomerular sclerosis (FSGS), IgA nephropathy (IgAN), and membranous nephropathy (MN).
However, the expression and the potential roles of RANKL and RANK in diabetic nephropathy (DN) remain unclear.
Irbesartan (Irb) has beneficial effects against diabetes-induced renal damage, but its mechanisms are poorly understood.
Our present study investigated the effects of Irb in DN and whether the renal protective effects of Irb are mediated by RANKL/RANK and the downstream NF-κB pathway in db/db mice.
Our results showed that db/db mice revealed severe metabolic abnormalities, renal dysfunction, podocyte injury, and increased MCP-1; these symptoms were reversed by Irb.
At the molecular level, RANKL and RANK were overexpressed in the kidneys of db/db mice and Irb downregulated RANKL and RANK and inhibited the downstream NF-κB pathway.
Our study suggests that Irb can ameliorate DN by suppressing the RANKL-RANK-NF-κB pathway.
American Psychological Association (APA)
Chen, Xiao-wen& Du, Xiao-yan& Wang, Yu-Xian& Wang, Jian-Cheng& Liu, Wen-Ting& Chen, Wen-Jing…[et al.]. 2016. Irbesartan Ameliorates Diabetic Nephropathy by Suppressing the RANKL-RANK-NF-κB Pathway in Type 2 Diabetic dbdb Mice. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110930
Modern Language Association (MLA)
Chen, Xiao-wen…[et al.]. Irbesartan Ameliorates Diabetic Nephropathy by Suppressing the RANKL-RANK-NF-κB Pathway in Type 2 Diabetic dbdb Mice. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1110930
American Medical Association (AMA)
Chen, Xiao-wen& Du, Xiao-yan& Wang, Yu-Xian& Wang, Jian-Cheng& Liu, Wen-Ting& Chen, Wen-Jing…[et al.]. Irbesartan Ameliorates Diabetic Nephropathy by Suppressing the RANKL-RANK-NF-κB Pathway in Type 2 Diabetic dbdb Mice. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110930