![](/images/graphics-bg.png)
MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia
Joint Authors
Chen, Ning
Yang, Yi
Fan, Jingjing
Kou, Xianjuan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Sarcopenia has been defined as the aging-related disease with the declined mass, strength, and function of skeletal muscle, which is the major cause of frailty and falls in elders.
The activation of inflammatory signal pathways due to diseases and aging is suggested to reveal the critical impact on sarcopenia.
Several proinflammatory cytokines, especially interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), play crucial roles in modulation of inflammatory signaling pathway during the aging-related loss of skeletal muscle.
MicroRNAs (miRNAs) have emerged as the important regulators for the mass and functional maintenance of skeletal muscle through regulating gene expression of proinflammatory cytokines.
In this paper, we have systematically discussed regulatory mechanisms of miRNAs for the expression and secretion of inflammatory cytokines during sarcopenia, which will provide some novel targets and therapeutic strategies for controlling aging-related atrophy of skeletal muscle and corresponding chronic inflammatory diseases.
American Psychological Association (APA)
Fan, Jingjing& Kou, Xianjuan& Yang, Yi& Chen, Ning. 2016. MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110932
Modern Language Association (MLA)
Fan, Jingjing…[et al.]. MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia. Mediators of Inflammation No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1110932
American Medical Association (AMA)
Fan, Jingjing& Kou, Xianjuan& Yang, Yi& Chen, Ning. MicroRNA-Regulated Proinflammatory Cytokines in Sarcopenia. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110932
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110932