HIV Progression Perturbs the Balance of the Cell-Mediated and Anti-Inflammatory Adaptive and Innate Mycobacterial Immune Response
Joint Authors
DiNardo, Andrew R.
Mandalakas, Anna M.
Maphalala, Gugu
Mtetwa, Godwin
Mndzebele, Temhlanga
Ustero, Piluca
Hlatshwayo, Makhosazana
Mace, Emily M.
Orange, Jordan S.
Makedonas, George
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Our objective is to understand how HIV infection increases the risk of progression from latent tuberculosis (TB) to active disease.
We understand now that immunity is a balance of competing immune responses by multiple cell types.
Since T-lymphocyte production of interferon-gamma (IFN-γ) in response to Mycobacterium tuberculosis (Mtb) antigens fails to differentiate disease from latent infection, we applied a comprehensive profiling methodology to define immune biomarkers that reliably predict a patient’s TB risk.
Methods.
We established a cohort of HIV-infected adults with TB disease from Swaziland.
Multiparametric flow cytometry was used to quantify the mycobacterial-specific anti-inflammatory (IL-4 and IL-10) and proinflammatory (IFN-γ) immune response.
Results.
From 12 HIV-infected Swaziland patients with TB disease, the CD4+, CD8+, Double Negative, and CD56+CD3− lymphocytes increase their IL-4 : IFN-γ ratio as HIV disease worsens (Spearman r of −0.59; −0.59; −0.60; and −0.59, resp.; p<0.05).
Similarly, HIV severity is associated with an increased IL-10 : IFN-γ ratio (Spearman r of −0.76; p=0.01).
Conclusion.
As HIV disease progresses, both the adaptive and innate branches skew away from an inflammatory and towards anti-inflammatory phenotype.
American Psychological Association (APA)
DiNardo, Andrew R.& Mandalakas, Anna M.& Maphalala, Gugu& Mtetwa, Godwin& Mndzebele, Temhlanga& Ustero, Piluca…[et al.]. 2016. HIV Progression Perturbs the Balance of the Cell-Mediated and Anti-Inflammatory Adaptive and Innate Mycobacterial Immune Response. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110933
Modern Language Association (MLA)
DiNardo, Andrew R.…[et al.]. HIV Progression Perturbs the Balance of the Cell-Mediated and Anti-Inflammatory Adaptive and Innate Mycobacterial Immune Response. Mediators of Inflammation No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1110933
American Medical Association (AMA)
DiNardo, Andrew R.& Mandalakas, Anna M.& Maphalala, Gugu& Mtetwa, Godwin& Mndzebele, Temhlanga& Ustero, Piluca…[et al.]. HIV Progression Perturbs the Balance of the Cell-Mediated and Anti-Inflammatory Adaptive and Innate Mycobacterial Immune Response. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110933