![](/images/graphics-bg.png)
Interaction between ANXA1 and GATA-3 in Immunosuppression of CD4+ T Cells
Joint Authors
Huang, Peng
Zhou, Yuxiang
Liu, Zan
Zhang, Pihong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Decreased Th1/Th2 ratio is one of the major characteristics of immunosuppression in sepsis.
Both membrane adhesive protein Annexin-A1 (ANXA1) and transcription factor GATA-3 have been reported to play important roles in T cell differentiation.
However, the relationship between ANXA1 and GATA-3 in Th1/Th2 shift is unknown.
Our study investigated the interaction effects of ANXA1 and GATA-3 to influence T cell differentiation in CD4+ T cells.
We found that GATA-3 and ANXA1 were coexpressed on Th0/Th1/Th2 cytoplasm and nuclear.
Overexpressed ANXA1 significantly increased the expression of IFNγ and reduced IL-4 expression in T cells, while ANXA1-silenced T cells exhibited decreased production of IFNγ and increased production of IL-4.
Knockdown of ANXA1 promoted higher expression level of GATA-3 and low level of T-box transcription factor (T-bet/Tbx21).
Further study demonstrated that ANXA1 regulated GATA-3 expression through the formyl peptide receptor like-1 (FPRL-1) downstream signaling pathways ERK and PKB/Akt.
These results suggested that ANXA1 modulates GATA-3/T-bet expression induced Th0/Th1 differentiation.
Moreover, we found that GATA-3 inhibited ANXA1 expression by binding to its promoter for the first time.
It is proposed that the interactions between ANXA1 and GATA-3 may provide clues to understand the immunosuppression and have potential as new therapeutic targets in immunotherapy after sepsis.
American Psychological Association (APA)
Huang, Peng& Zhou, Yuxiang& Liu, Zan& Zhang, Pihong. 2016. Interaction between ANXA1 and GATA-3 in Immunosuppression of CD4+ T Cells. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110942
Modern Language Association (MLA)
Huang, Peng…[et al.]. Interaction between ANXA1 and GATA-3 in Immunosuppression of CD4+ T Cells. Mediators of Inflammation No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1110942
American Medical Association (AMA)
Huang, Peng& Zhou, Yuxiang& Liu, Zan& Zhang, Pihong. Interaction between ANXA1 and GATA-3 in Immunosuppression of CD4+ T Cells. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110942