Association between Serum Interleukin-17A Level and High-Altitude Deacclimatization Syndrome
Joint Authors
He, Binfeng
Li, Hongli
Hu, Mingdong
Dong, Weijie
Wei, Zhenghua
Li, Jin
Yao, Wei
Guo, Xiaolan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
High-altitude deacclimatization syndrome (HADAS) is emerging as a severe public health issue that threatens the quality of life of individuals who return to lower altitude from high altitude.
In this study, we measured serum levels of SOD, MDA, IL-17A, IL-10, TNF-α, and HADAS score in HADAS subjects at baseline and 50th and 100th days and to evaluate the relationship between interleukins, including IL-17A, and HADAS.
Our data showed that and the serum IL-17A levels and HADAS score decreased over time in the HADAS group, and serum IL-17A levels were significantly higher in the HADAS group at baseline and 50th day compared with controls ( p < 0.05 ).
Furthermore, baseline serum levels of MDA and TNF-α were significantly higher, while SOD and IL-10 levels were lower in HADAS subjects compared with controls ( p < 0.05 ).
It is interesting that serum levels of IL-17A were clearly interrelated with HADAS incidence and severity ( p < 0.05 ).
ROC curve analysis showed that combined serum IL-17A and IL-10 levels were a better predictor of HADAS incidence than serum levels of IL-17A or IL-10 alone.
These data suggest that serum levels of IL-17A are a novel predictive index of HADAS.
American Psychological Association (APA)
He, Binfeng& Li, Hongli& Hu, Mingdong& Dong, Weijie& Wei, Zhenghua& Li, Jin…[et al.]. 2016. Association between Serum Interleukin-17A Level and High-Altitude Deacclimatization Syndrome. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1110943
Modern Language Association (MLA)
He, Binfeng…[et al.]. Association between Serum Interleukin-17A Level and High-Altitude Deacclimatization Syndrome. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1110943
American Medical Association (AMA)
He, Binfeng& Li, Hongli& Hu, Mingdong& Dong, Weijie& Wei, Zhenghua& Li, Jin…[et al.]. Association between Serum Interleukin-17A Level and High-Altitude Deacclimatization Syndrome. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1110943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110943