CETP Lowers TLR4 Expression Which Attenuates the Inflammatory Response Induced by LPS and Polymicrobial Sepsis
Joint Authors
Camara, Niels Olsen Saraiva
Venancio, Tatiana Martins
Machado, Roberta Marcondes
Castoldi, Angela
Amano, Mariane Tami
Nunes, Valeria Sutti
Quintao, Eder Carlos Rocha
Soriano, Francisco Garcia
Cazita, Patrícia Miralda
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Sepsis is a systemic inflammatory response to infection eliciting high mortality rate which is a serious health problem.
Despite numerous studies seeking for therapeutic alternatives, the mechanisms involved in this disease remain elusive.
In this study we evaluated the influence of cholesteryl ester transfer protein (CETP), a glycoprotein that promotes the transfer of lipids between lipoproteins, on the inflammatory response in mice.
Human CETP transgenic mice were compared to control mice (wild type, WT) after polymicrobial sepsis induced by cecal ligation and puncture (CLP), aiming at investigating their survival rate and inflammatory profiles.
Macrophages from the peritoneal cavity were stimulated with LPS in the presence or absence of recombinant CETP for phenotypic and functional studies.
In comparison to WT mice, CETP mice showed higher survival rate, lower IL-6 plasma concentration, and decreased liver toll-like receptor 4 (TLR4) and acyloxyacyl hydrolase (AOAH) protein.
Moreover, macrophages from WT mice to which recombinant human CETP was added decreased LPS uptake, TLR4 expression, NF-κB activation and IL-6 secretion.
This raises the possibility for new therapeutic tools in sepsis while suggesting that lowering CETP by pharmacological inhibitors should be inconvenient in the context of sepsis and infectious diseases.
American Psychological Association (APA)
Venancio, Tatiana Martins& Machado, Roberta Marcondes& Castoldi, Angela& Amano, Mariane Tami& Nunes, Valeria Sutti& Quintao, Eder Carlos Rocha…[et al.]. 2016. CETP Lowers TLR4 Expression Which Attenuates the Inflammatory Response Induced by LPS and Polymicrobial Sepsis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110945
Modern Language Association (MLA)
Venancio, Tatiana Martins…[et al.]. CETP Lowers TLR4 Expression Which Attenuates the Inflammatory Response Induced by LPS and Polymicrobial Sepsis. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1110945
American Medical Association (AMA)
Venancio, Tatiana Martins& Machado, Roberta Marcondes& Castoldi, Angela& Amano, Mariane Tami& Nunes, Valeria Sutti& Quintao, Eder Carlos Rocha…[et al.]. CETP Lowers TLR4 Expression Which Attenuates the Inflammatory Response Induced by LPS and Polymicrobial Sepsis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110945
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110945