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Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid
Joint Authors
Yang, Woo Seok
Yoo, Byong Chul
Kim, Jong-Hoon
Kim, Seung Cheol
Kim, Yong
Kim, Shi Hyoung
Kim, Yun Hwan
Kim, Kyung-Hee
Cho, Jae Youl
Hong, Sungyoul
Park, Jae Gwang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Anthraquinone compounds are one of the abundant polyphenols found in fruits, vegetables, and herbs.
However, the in vivo anti-inflammatory activity and molecular mechanisms of anthraquinones have not been fully elucidated.
We investigated the activity of anthraquinones using acute inflammatory and nociceptive experimental conditions.
Anthraquinone-2-carboxylic acid (9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid, AQCA), one of the major anthraquinones identified from Brazilian taheebo, ameliorated various inflammatory and algesic symptoms in EtOH/HCl- and acetylsalicylic acid- (ASA-) induced gastritis, arachidonic acid-induced edema, and acetic acid-induced abdominal writhing without displaying toxic profiles in body and organ weight, gastric irritation, or serum parameters.
In addition, AQCA suppressed the expression of inflammatory genes such as cyclooxygenase- (COX-) 2 in stomach tissues and lipopolysaccharide- (LPS-) treated RAW264.7 cells.
According to reporter gene assay and immunoblotting analyses, AQCA inhibited activation of the nuclear factor- (NF-) κB and activator protein- (AP-) 1 pathways by suppression of upstream signaling involving interleukin-1 receptor-associated kinase 4 (IRAK1), p38, Src, and spleen tyrosine kinase (Syk).
Our data strongly suggest that anthraquinones such as AQCA act as potent anti-inflammatory and antinociceptive components in vivo, thus contributing to the immune regulatory role of fruits and herbs.
American Psychological Association (APA)
Park, Jae Gwang& Kim, Seung Cheol& Kim, Yun Hwan& Yang, Woo Seok& Kim, Yong& Hong, Sungyoul…[et al.]. 2016. Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110949
Modern Language Association (MLA)
Park, Jae Gwang…[et al.]. Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1110949
American Medical Association (AMA)
Park, Jae Gwang& Kim, Seung Cheol& Kim, Yun Hwan& Yang, Woo Seok& Kim, Yong& Hong, Sungyoul…[et al.]. Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110949