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Histamine and Immune Biomarkers in CNS Disorders
Joint Authors
Cacabelos, Ramón
Torrellas, Clara
López-Muñoz, Francisco
Fernández-Novoa, Lucía
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Neuroimmune dysregulation is a common phenomenon in different forms of central nervous system (CNS) disorders.
Cross-links between central and peripheral immune mechanisms appear to be disrupted as reflected by a series of immune markers (CD3, CD4, CD7, HLA-DR, CD25, CD28, and CD56) which show variability in brain disorders such as anxiety, depression, psychosis, stroke, Alzheimer’s disease, Parkinson’s disease, attention-deficit hyperactivity disorder, migraine, epilepsy, vascular dementia, mental retardation, cerebrovascular encephalopathy, multiple sclerosis, brain tumors, cranial nerve neuropathies, mental retardation, and posttraumatic brain injury.
Histamine (HA) is a pleiotropic monoamine involved in several neurophysiological functions, neuroimmune regulation, and CNS pathogenesis.
Changes in brain HA show an age- and sex-related pattern, and alterations in brain HA levels are present in different CNS regions of patients with Alzheimer’s disease (AD).
Brain HA in neuronal and nonneuronal compartments plays a dual role (neurotrophic versus neurotoxic) in a tissue-specific manner.
Pathogenic mechanisms associated with neuroimmune dysregulation in AD involve HA, interleukin-1β, and TNF-α, whose aberrant expression contributes to neuroinflammation as an aggravating factor for neurodegeneration and premature neuronal death.
American Psychological Association (APA)
Cacabelos, Ramón& Torrellas, Clara& Fernández-Novoa, Lucía& López-Muñoz, Francisco. 2016. Histamine and Immune Biomarkers in CNS Disorders. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110950
Modern Language Association (MLA)
Cacabelos, Ramón…[et al.]. Histamine and Immune Biomarkers in CNS Disorders. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1110950
American Medical Association (AMA)
Cacabelos, Ramón& Torrellas, Clara& Fernández-Novoa, Lucía& López-Muñoz, Francisco. Histamine and Immune Biomarkers in CNS Disorders. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110950