Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells
Joint Authors
Xia, Weiwei
Gu, Jun
Chen, Hongbing
Zhang, Aihua
Jia, Zhanjun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Both statins and klotho have been shown to be beneficial in vascular diseases.
Interleukin- (IL-) 6 is evidenced as an indicator reflecting the stability of atherosclerotic plaque and involved in the pathogenesis of artery atherosclerosis.
However, the relationship between statin, klotho, and IL-6 under an inflammatory environment is unknown.
Using primary human umbilical vein endothelial cells (HUVECs), pravastatin dose-dependently induced klotho expression in contrast to remarkable suppression to IL-6 expressions determined by qRT-PCR.
Moreover, TNF-α-induced IL-6 was partly but significantly blunted by pravastatin detected by ELISA.
To further study the role of klotho in modulating IL-6 expression, endothelial cells with klotho overexpression were treated with TNF-α.
Importantly, TNF-α-induced IL-6 production was markedly attenuated in klotho-overexpressed cells.
In agreement with in vitro data, a marked reduction of klotho mRNA expression was found in isolated peripheral blood mononuclear cells (PBMCs) from patients with atherosclerosis.
Together, these data suggested that pravastatin could suppress IL-6 production via promoting klotho expression in endothelial cells under inflammatory stimuli.
American Psychological Association (APA)
Xia, Weiwei& Zhang, Aihua& Jia, Zhanjun& Gu, Jun& Chen, Hongbing. 2016. Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110963
Modern Language Association (MLA)
Xia, Weiwei…[et al.]. Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells. Mediators of Inflammation No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1110963
American Medical Association (AMA)
Xia, Weiwei& Zhang, Aihua& Jia, Zhanjun& Gu, Jun& Chen, Hongbing. Klotho Contributes to Pravastatin Effect on Suppressing IL-6 Production in Endothelial Cells. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110963
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110963