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Association between IgG4 Autoantibody and Complement Abnormalities in Systemic Lupus Erythematosus
Joint Authors
Cai, Jun
Lan, Qiaofen
Liao, Huanjin
Pan, Qingjun
Guo, Linjie
Wu, Jing
Peng, Yanxia
He, Yiming
Liu, Hua-feng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In order to investigate the association between IgG4 autoantibody and complement abnormalities in systemic lupus erythematosus (SLE), 72 newly diagnosed SLE patients, 67 rheumatoid arthritis (RA) patients, and 41 healthy normals were employed.
Serum levels of antinuclear IgG4 and IgG4-specific IgM-rheumatoid factor (RF) were measured, and the correlations between serum levels of antinuclear IgG4 and several clinical parameters were analyzed.
Also, the levels of IgG subclasses, C1q, and C3 deposition in lupus nephritis (LN) were detected.
The results showed that serum levels of antinuclear IgG4 were higher in SLE patients relative to healthy normals (P<0.01).
Serum levels of antinuclear IgG4 in SLE patients were positively correlated with serum levels of total IgG4, albumin, and C3 (r=0.61, P<0.05; r=0.40, P<0.05; and r=0.54, P<0.05, resp.) and negatively correlated with 24-hour urinary protein (r=0.49, P<0.05).
Serum levels of IgG4-specific IgM-RF were higher in RA patients than in SLE patients (P<0.001).
Also, the ratio of the deposition score for IgG4/(IgG1 + IgG2 + IgG3 + IgG4) was negatively correlated with the score for C1q and C3 deposition in LN (r=0.34, P<0.05; r=0.51, P<0.01, resp.).
In summary, the IgG4 autoantibody may dampen the inflammatory response in SLE, thus maybe providing a novel therapeutic target for SLE.
American Psychological Association (APA)
Pan, Qingjun& Guo, Linjie& Wu, Jing& Cai, Jun& Liao, Huanjin& Lan, Qiaofen…[et al.]. 2016. Association between IgG4 Autoantibody and Complement Abnormalities in Systemic Lupus Erythematosus. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1110964
Modern Language Association (MLA)
Pan, Qingjun…[et al.]. Association between IgG4 Autoantibody and Complement Abnormalities in Systemic Lupus Erythematosus. Mediators of Inflammation No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1110964
American Medical Association (AMA)
Pan, Qingjun& Guo, Linjie& Wu, Jing& Cai, Jun& Liao, Huanjin& Lan, Qiaofen…[et al.]. Association between IgG4 Autoantibody and Complement Abnormalities in Systemic Lupus Erythematosus. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1110964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110964