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The Vascular Endothelial Growth Factors-Expressing Character of Mesenchymal Stem Cells Plays a Positive Role in Treatment of Acute Lung Injury In Vivo
Joint Authors
Liu, Songqiao
Qiu, Haibo
Yang, Yi
Hu, Shuling
Xu, Xiuping
Li, Jinze
Liu, Airan
Han, Jibin
Liu, Ling
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Recently, mesenchymal stem cells (MSC) have been proved to be beneficial in acute respiratory distress syndrome (ARDS).
Vascular endothelial growth factor (VEGF) is an important angiogenesis factor that MSC release.
However, the precise role of VEGF-expressing character of MSC in the MSC treatment for ARDS remains obscure.
Here, we firstly knocked down the gene VEGF in MSC (MSC-ShVEGF) with lentiviral transduction.
Then we injected the MSC-ShVEGF to rats with lipopolysaccharide-induced acute lung injury (ALI) via the tail vein.
Data showed that MSC transplantation significantly increased VEGF levels in the lung, reduced lung permeability, protected lung endothelium from apoptosis, facilitated VE-cadherin recovery, controlled inflammation, and attenuated lung injury.
However, VEGF gene knockdown in MSC led to relatively insufficient VEGF expression in the injured lung and significantly diminished the therapeutic effects of MSC on ALI, suggesting an important role of VEGF-expressing behavior of MSC in the maintenance of VEGF in the lung and the MSC treatment for ALI.
Hence, we conclude that MSC restores the lung permeability and attenuates lung injury in rats with ALI in part by maintaining a “sufficient” VEGF level in the lung and the VEGF-expressing character of MSC plays a positive role in the therapeutic effects of MSC on ARDS.
American Psychological Association (APA)
Yang, Yi& Hu, Shuling& Xu, Xiuping& Li, Jinze& Liu, Airan& Han, Jibin…[et al.]. 2016. The Vascular Endothelial Growth Factors-Expressing Character of Mesenchymal Stem Cells Plays a Positive Role in Treatment of Acute Lung Injury In Vivo. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110965
Modern Language Association (MLA)
Yang, Yi…[et al.]. The Vascular Endothelial Growth Factors-Expressing Character of Mesenchymal Stem Cells Plays a Positive Role in Treatment of Acute Lung Injury In Vivo. Mediators of Inflammation No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1110965
American Medical Association (AMA)
Yang, Yi& Hu, Shuling& Xu, Xiuping& Li, Jinze& Liu, Airan& Han, Jibin…[et al.]. The Vascular Endothelial Growth Factors-Expressing Character of Mesenchymal Stem Cells Plays a Positive Role in Treatment of Acute Lung Injury In Vivo. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1110965
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110965