Metabolism Is Central to Tolerogenic Dendritic Cell Function
Joint Authors
Sim, Wen Jing
Ahl, Patricia Jennifer
Connolly, John Edward
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Immunological tolerance is a fundamental tenant of immune homeostasis and overall health.
Self-tolerance is a critical component of the immune system that allows for the recognition of self, resulting in hyporeactivity instead of immunogenicity.
Dendritic cells are central to the establishment of dominant immune tolerance through the secretion of immunosuppressive cytokines and regulatory polarization of T cells.
Cellular metabolism holds the key to determining DC immunogenic or tolerogenic cell fate.
Recent studies have demonstrated that dendritic cell maturation leads to a shift toward a glycolytic metabolic state and preferred use of glucose as a carbon source.
In contrast, tolerogenic dendritic cells favor oxidative phosphorylation and fatty acid oxidation.
This dichotomous metabolic reprogramming of dendritic cells drives differential cellular function and plays a role in pathologies, such as autoimmune disease.
Pharmacological alterations in metabolism have promising therapeutic potential.
American Psychological Association (APA)
Sim, Wen Jing& Ahl, Patricia Jennifer& Connolly, John Edward. 2016. Metabolism Is Central to Tolerogenic Dendritic Cell Function. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110973
Modern Language Association (MLA)
Sim, Wen Jing…[et al.]. Metabolism Is Central to Tolerogenic Dendritic Cell Function. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1110973
American Medical Association (AMA)
Sim, Wen Jing& Ahl, Patricia Jennifer& Connolly, John Edward. Metabolism Is Central to Tolerogenic Dendritic Cell Function. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110973
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110973