Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis
Joint Authors
Zheng, Wei
Wang, Qilan
Lu, Xiaohua
Shi, Qiangqiang
Zou, Junhui
Tao, Yanduo
Wang, Pu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Dracocephalum heterophyllum (DH) is a Chinese herbal medicine used in treating hepatitis.
However, the protective effects and pharmacological mechanisms of DH in hepatitis are unknown.
In this study, we found that pretreatment with DH extract significantly ameliorated liver injury and suppressed the production of inflammatory cytokines, including tumor necrosis factor (TNF-α) and interferon-γ (IFN-γ) in Concanavalin A- (ConA-) induced hepatitis (CIH).
DH recruited more CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) to the liver and suppressed infiltration of macrophages (Kupffer cells) in the liver.
The present work explores DH as an effective hepatoprotective medicine to inhibit inflammation and liver injury caused by hepatitis.
American Psychological Association (APA)
Zheng, Wei& Wang, Qilan& Lu, Xiaohua& Shi, Qiangqiang& Zou, Junhui& Tao, Yanduo…[et al.]. 2016. Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1110975
Modern Language Association (MLA)
Zheng, Wei…[et al.]. Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1110975
American Medical Association (AMA)
Zheng, Wei& Wang, Qilan& Lu, Xiaohua& Shi, Qiangqiang& Zou, Junhui& Tao, Yanduo…[et al.]. Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1110975
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110975