Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF-α and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients
Joint Authors
Gabibov, A. G.
Belogurov, Alexey
Lomakin, Yakov
Glagoleva, Irina
Stepanov, Alexey
Zakharov, Konstantin
Okunola, John
Smirnov, Ivan
Genkin, Dmitry
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic encephalomyelitis (EAE).
Within the frames of the successfully completed phase I clinical trial, we investigated changes in the serum cytokine profile after Xemys administration in MS patients.
We observed a statistically significant decrease of MCP-1/CCL2, MIP-1β/CCL4, IL-7, and IL-2 at the time of study completion.
In contrast, the serum levels of TNF-α were remarkably elevated.
Our data suggest that the administration of Xemys leads to a normalization of cytokine status in MS patients to values commonly reported for healthy subjects.
These data are an important contribution for the upcoming Xemys clinical trials.
American Psychological Association (APA)
Lomakin, Yakov& Belogurov, Alexey& Glagoleva, Irina& Stepanov, Alexey& Zakharov, Konstantin& Okunola, John…[et al.]. 2016. Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF-α and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1110979
Modern Language Association (MLA)
Lomakin, Yakov…[et al.]. Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF-α and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1110979
American Medical Association (AMA)
Lomakin, Yakov& Belogurov, Alexey& Glagoleva, Irina& Stepanov, Alexey& Zakharov, Konstantin& Okunola, John…[et al.]. Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF-α and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1110979
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110979
