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Pleiotropic Effects of IL-2 on Cancer: Its Role in Cervical Cancer
Joint Authors
Valle-Mendiola, Arturo
Gutiérrez-Hoya, Adriana
Lagunas-Cruz, María del Carmen
Weiss-Steider, Benny
Soto-Cruz, Isabel
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
IL-2 receptor (IL-2R) signalling is critical for normal lymphocyte proliferation, but its role in cervical cancer is not fully understood.
The receptor is composed of three chains: IL-2α, IL-2β, and IL-2γ.
Intracellular signalling is initiated by ligand-induced heterodimerization of the IL-2β and IL-2γ chains, resulting in the activation of multiple intracellular kinases.
Recently, IL-2R was shown to be expressed on nonhaematopoietic cells, especially on several types of tumour cells.
However, the function of this receptor on malignant cells has not been clearly defined.
The expression of IL-2R and the production of IL-2 in cervical cancer cells have been documented as well as expression of molecules of the JAK-STAT pathway.
In the current review we have highlighted the differences in the responses of molecules downstream from the IL-2R in normal lymphocytes and tumour cells that could explain the presence of tumour cells in an environment in which cytotoxic lymphocytes also exist and compete and also the effect of different concentrations of IL-2 that could activate effector cells of the immune system cells, which favour the elimination of tumour cells, or concentrations that may promote a regulatory microenvironment in which tumour cells can easily grow.
American Psychological Association (APA)
Valle-Mendiola, Arturo& Gutiérrez-Hoya, Adriana& Lagunas-Cruz, María del Carmen& Weiss-Steider, Benny& Soto-Cruz, Isabel. 2016. Pleiotropic Effects of IL-2 on Cancer: Its Role in Cervical Cancer. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1110980
Modern Language Association (MLA)
Valle-Mendiola, Arturo…[et al.]. Pleiotropic Effects of IL-2 on Cancer: Its Role in Cervical Cancer. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1110980
American Medical Association (AMA)
Valle-Mendiola, Arturo& Gutiérrez-Hoya, Adriana& Lagunas-Cruz, María del Carmen& Weiss-Steider, Benny& Soto-Cruz, Isabel. Pleiotropic Effects of IL-2 on Cancer: Its Role in Cervical Cancer. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1110980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110980