![](/images/graphics-bg.png)
SOCS1 Mimetic Peptide Suppresses Chronic Intraocular Inflammatory Disease (Uveitis)
Joint Authors
Larkin, Joseph
He, Chang
Mattapallil, Mary J.
Sun, Lin
Egwuagu, Charles E.
Yu, Cheng-Rong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-15
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Uveitis is a potentially sight-threatening disease characterized by repeated cycles of remission and recurrent inflammation.
The JAK/STAT pathway regulates the differentiation of pathogenic Th1 and Th17 cells that mediate uveitis.
A SOCS1 mimetic peptide (SOCS1-KIR) that inhibits JAK2/STAT1 pathways has recently been shown to suppress experimental autoimmune uveitis (EAU).
However, it is not clear whether SOCS1-KIR ameliorated uveitis by targeting JAK/STAT pathways of pathogenic lymphocytes or via inhibition of macrophages and antigen-presenting cells that also enter the retina during EAU.
To further investigate mechanisms that mediate SOCS1-KIR effects and evaluate the efficacy of SOCS1-KIR as an investigational drug for chronic uveitis, we induced EAU in rats by adoptive transfer of uveitogenic T-cells and monitored disease progression and severity by slit-lamp microscopy, histology, and optical coherence tomography.
Topical administration of SOCS1-KIR ameliorated acute and chronic posterior uveitis by inhibiting Th17 cells and the recruitment of inflammatory cells into retina while promoting expansion of IL-10-producing Tregs.
We further show that SOCS1-KIR conferred protection of resident retinal cells that play critical role in vision from cytotoxic effects of inflammatory cytokines by downregulating proapoptotic genes.
Thus, SOCS1-KIR suppresses uveitis and confers neuroprotective effects and might be exploited as a noninvasive treatment for chronic uveitis.
American Psychological Association (APA)
He, Chang& Yu, Cheng-Rong& Mattapallil, Mary J.& Sun, Lin& Larkin, Joseph& Egwuagu, Charles E.. 2016. SOCS1 Mimetic Peptide Suppresses Chronic Intraocular Inflammatory Disease (Uveitis). Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1110985
Modern Language Association (MLA)
He, Chang…[et al.]. SOCS1 Mimetic Peptide Suppresses Chronic Intraocular Inflammatory Disease (Uveitis). Mediators of Inflammation No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1110985
American Medical Association (AMA)
He, Chang& Yu, Cheng-Rong& Mattapallil, Mary J.& Sun, Lin& Larkin, Joseph& Egwuagu, Charles E.. SOCS1 Mimetic Peptide Suppresses Chronic Intraocular Inflammatory Disease (Uveitis). Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1110985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110985