Ethanol Extract of Sanguisorbae Radix Inhibits Mast Cell Degranulation and Suppresses 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions
Joint Authors
Ma, Jin Yeul
Yang, Ju-Hye
Yoo, Jae-Myung
Cho, Won-Kyung
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Sanguisorbae Radix (SR) is well known as herbal medicine named “Zi-Yu” in Korea, which is the dried roots of Sanguisorba officinalis L.
(Rosacease).
We investigated the underlying mechanism on the inhibition of atopic dermatitis (AD) of an ethanol extract of SR (ESR) using 2,4-dinitrochlorobenzene- (DNCB-) induced AD mice model.
Oral administration of ESR significantly suppressed DNCB-induced AD-like symptoms such as scratching behavior, ear thickness, epidermal thickness, and IgE levels.
To investigate the effects of ESR treatment on degranulation of IgE/Ag-activated mouse bone marrow-derived mast cells (BMMCs), we measured the release of β-hexosaminidase (β-HEX, degranulation marker).
ESR decreased the infiltration of eosinophils and mast cells into the AD skin lesions.
Furthermore, ESR significantly inhibited degranulation of IgE/Ag-activated BMMCs.
We have demonstrated that ESR decreased AD symptoms in mice and inhibits degranulation of IgE/Ag-activated mast cells.
Our study suggests that ESR may serve as a potential therapeutic candidate for the treatment of AD symptoms.
American Psychological Association (APA)
Yang, Ju-Hye& Yoo, Jae-Myung& Cho, Won-Kyung& Ma, Jin Yeul. 2016. Ethanol Extract of Sanguisorbae Radix Inhibits Mast Cell Degranulation and Suppresses 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1110988
Modern Language Association (MLA)
Yang, Ju-Hye…[et al.]. Ethanol Extract of Sanguisorbae Radix Inhibits Mast Cell Degranulation and Suppresses 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1110988
American Medical Association (AMA)
Yang, Ju-Hye& Yoo, Jae-Myung& Cho, Won-Kyung& Ma, Jin Yeul. Ethanol Extract of Sanguisorbae Radix Inhibits Mast Cell Degranulation and Suppresses 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1110988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110988