Increased KappaLambda Hybrid Antibody in Serum Is a Novel Biomarker Related to Disease Activity and Inflammation in Rheumatoid Arthritis
Joint Authors
Yi, Lang
Hao, Mingju
Lu, Tian
Lin, Guigao
Chen, Lida
Gao, Ming
Fan, Gaowei
Zhang, Dong
Wang, Guojing
Yang, Xin
Li, Yulong
Zhang, Kuo
Zhang, Rui
Han, Yanxi
Wang, Lunan
Li, Jinming
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The κ / λ hybrid antibodies in normal human serum were reported recently, but their clinical relevance has not yet been explored.
Rheumatoid arthritis (RA) is one of the major joint diseases, and the early diagnosis and treatment of RA remain a challenge.
Here, we developed a double-sandwich enzyme-linked immunosorbent assay system to quantify relative serum κ / λ hybrid antibody levels in RA patients, osteoarthritis (OA) patients, and healthy controls (HC) in order to assess their potential use as a serological biomarker of early disease and clinical activity and to preliminarily investigate their immunomodulatory roles in RA.
Surprisingly, we found that κ / λ hybrid antibody was markedly increased in both early and established RA.
Serum κ / λ hybrid antibody levels were significantly correlated with clinical indexes and inflammatory markers in RA.
Further analysis showed a positive correlation between κ / λ hybrid antibody levels and the 28-joint disease activity score (DAS28).
In conclusion, serum κ / λ hybrid antibodies in RA were identified for the first time.
High levels of κ / λ hybrid antibody may be a useful tool in distinguishing early RA from OA and HC.
We suggest κ / λ hybrid antibody as a marker for disease activity.
The increased κ / λ hybrid antibodies were associated with inflammatory conditions in RA.
American Psychological Association (APA)
Yi, Lang& Hao, Mingju& Lu, Tian& Lin, Guigao& Chen, Lida& Gao, Ming…[et al.]. 2016. Increased KappaLambda Hybrid Antibody in Serum Is a Novel Biomarker Related to Disease Activity and Inflammation in Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110989
Modern Language Association (MLA)
Yi, Lang…[et al.]. Increased KappaLambda Hybrid Antibody in Serum Is a Novel Biomarker Related to Disease Activity and Inflammation in Rheumatoid Arthritis. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1110989
American Medical Association (AMA)
Yi, Lang& Hao, Mingju& Lu, Tian& Lin, Guigao& Chen, Lida& Gao, Ming…[et al.]. Increased KappaLambda Hybrid Antibody in Serum Is a Novel Biomarker Related to Disease Activity and Inflammation in Rheumatoid Arthritis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1110989
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110989