M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b
Joint Authors
Volonté, Cinzia
Parisi, Chiara
Napoli, Giulia
Pelegrín, Pablo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Amyotrophic lateral sclerosis (ALS) is a most frequently occurring and severe form of motor neuron disease, causing death within 3–5 years from diagnosis and with a worldwide incidence of about 2 per 100,000 person-years.
Mutations in over twenty genes associated with familial forms of ALS have provided insights into the mechanisms leading to motor neuron death.
Moreover, mutations in two RNA binding proteins, TAR DNA binding protein 43 and fused in sarcoma, have raised the intriguing possibility that perturbations of RNA metabolism, including that of the small endogenous RNA molecules that repress target genes at the posttranscriptional level, that is, microRNAs, may contribute to disease pathogenesis.
At present, the mechanisms by which microglia actively participate to both toxic and neuroprotective actions in ALS constitute an important matter of research.
Among the pathways involved in ALS-altered microglia responses, in previous works we have uncovered the hyperactivation of P2X7 receptor by extracellular ATP and the overexpression of miR-125b, both leading to uncontrolled toxic M1 reactions.
In order to shed further light on the complexity of these processes, in this short review we will describe the M1/M2 functional imprinting of primary microglia and a role played by P2X7 and miR-125b in ALS microglia activation.
American Psychological Association (APA)
Parisi, Chiara& Napoli, Giulia& Pelegrín, Pablo& Volonté, Cinzia. 2016. M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110992
Modern Language Association (MLA)
Parisi, Chiara…[et al.]. M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b. Mediators of Inflammation No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1110992
American Medical Association (AMA)
Parisi, Chiara& Napoli, Giulia& Pelegrín, Pablo& Volonté, Cinzia. M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110992