Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance
Joint Authors
Gómez-Bañuelos, Eduardo
Navarro-Hernandez, Rosa Elena
Madrigal-Ruiz, Perla Monserrat
Guzmán-Ornelas, Milton-Omar
Corona Meraz, Fernanda-Isadora
Castro-Albarran, Jorge
Ruíz-Quezada, Sandra-Luz
Chavarria-Avila, Efraín
Petri, Marcelo-Herón
Ramírez-Cedano, Joel-Isidro
Aguilar-Aldrete, María-Elena
Ríos-Ibarra, Clara
Vázquez-Del Mercado, Mónica
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
In obesity there is a subclinical chronic low-grade inflammatory response where insulin resistance (IR) may develop.
Chemerin is secreted in white adipose tissue and promotes low-grade inflammatory process, where it expressed CMKLR1 receptor.
The role of chemerin and CMKLR1 in inflammatory process secondary to obesity is not defined yet.
Methods.
Cross-sectional study with 134 individuals classified as with and without obesity by body mass index (BMI) and IR.
Body fat storage measurements and metabolic and inflammatory markers were measured by routine methods.
Soluble chemerin and basal levels of insulin by ELISA and relative expression of CMKLR1 were evaluated with qPCR and 2 - Δ Δ C T method.
Results.
Differences ( P < 0.05 ) were observed between obesity and lean individuals in body fat storage measurements and metabolic-inflammatory markers.
Both CMKLR1 expression and chemerin levels were increased in obesity without IR.
Soluble chemerin levels correlate with adiposity and metabolic markers ( r = 8.8 % to 38.5%), P < 0.05 .
Conclusion.
The increment of CMKLR1 expression was associated with insulin production.
Increased serum levels of chemerin in obesity were observed, favoring a dysmetabolic response.
The results observed in this study suggest that both chemerin and CMKLR1 have opposite expression in the context of low-grade inflammatory response manifested in the development of IR.
American Psychological Association (APA)
Corona Meraz, Fernanda-Isadora& Navarro-Hernandez, Rosa Elena& Ruíz-Quezada, Sandra-Luz& Madrigal-Ruiz, Perla Monserrat& Castro-Albarran, Jorge& Chavarria-Avila, Efraín…[et al.]. 2016. Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110998
Modern Language Association (MLA)
Corona Meraz, Fernanda-Isadora…[et al.]. Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance. Mediators of Inflammation No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1110998
American Medical Association (AMA)
Corona Meraz, Fernanda-Isadora& Navarro-Hernandez, Rosa Elena& Ruíz-Quezada, Sandra-Luz& Madrigal-Ruiz, Perla Monserrat& Castro-Albarran, Jorge& Chavarria-Avila, Efraín…[et al.]. Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1110998
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110998