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Anti-Interleukin-1 BetaTumor Necrosis Factor-Alpha IgY Antibodies Reduce Pathological Allergic Responses in Guinea Pigs with Allergic Rhinitis
Joint Authors
Wei-xu, Hu
Wen-yun, Zhou
Xi-ling, Zhu
Zhu, Wen
Li-hua, Wu
Xiao-mu, Wu
Hui-ping, Wei
Wen-ding, Wang
Dan, He
Qin, Xiang
Guo-zhu, Hu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study aims to determine whether the combined blockade of IL-1β and TNF-α can alleviate the pathological allergic inflammatory reaction in the nasal mucosa and lung tissues in allergic rhinitis (AR) guinea pigs.
Healthy guinea pigs treated with saline were used as the healthy controls.
The AR guinea pigs were randomly divided into (1) the AR model group treated with intranasal saline; (2) the 0.1% nonspecific IgY treatment group; (3) the 0.1% anti-TNF-α IgY treatment group; (4) the 0.1% anti-IL-1β IgY treatment group; (5) the 0.1% combined anti-IL-1β and TNF-α IgY treatment group; and (6) the fluticasone propionate treatment group.
The inflammatory cells were evaluated using Wright’s staining.
Histopathology was examined using hematoxylin-eosin staining.
The results showed that the number of eosinophils was significantly decreased in the peripheral blood, nasal lavage fluid, and bronchoalveolar lavage fluid ( P < 0.05 ), and eosinophil, neutrophil, and lymphocyte infiltration and edema were significantly reduced or absent in the nasal mucosa and lung tissues ( P < 0.05 ) in the combined 0.1% anti-IL-1β- and TNF-α IgY-treated guinea pigs.
The data suggest that topical blockade of IL-1β and TNF-α could reduce pathological allergic inflammation in the nasal mucosa and lung tissues in AR guinea pigs.
American Psychological Association (APA)
Wei-xu, Hu& Wen-yun, Zhou& Xi-ling, Zhu& Zhu, Wen& Li-hua, Wu& Xiao-mu, Wu…[et al.]. 2016. Anti-Interleukin-1 BetaTumor Necrosis Factor-Alpha IgY Antibodies Reduce Pathological Allergic Responses in Guinea Pigs with Allergic Rhinitis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111001
Modern Language Association (MLA)
Wei-xu, Hu…[et al.]. Anti-Interleukin-1 BetaTumor Necrosis Factor-Alpha IgY Antibodies Reduce Pathological Allergic Responses in Guinea Pigs with Allergic Rhinitis. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111001
American Medical Association (AMA)
Wei-xu, Hu& Wen-yun, Zhou& Xi-ling, Zhu& Zhu, Wen& Li-hua, Wu& Xiao-mu, Wu…[et al.]. Anti-Interleukin-1 BetaTumor Necrosis Factor-Alpha IgY Antibodies Reduce Pathological Allergic Responses in Guinea Pigs with Allergic Rhinitis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111001