Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice
Joint Authors
Wang, Xiangrui
Yu, Weifeng
Xu, Huan
Zhao, Yanhua
Huang, Lili
Wu, Guangxi
Zhu, Mengyi
Tian, Jie
Wang, Hao
Yang, Liqun
Su, Diansan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Postoperative cognitive dysfunction (POCD) increases morbidity and mortality after surgery.
But the underlying mechanism is not clear yet.
While age is now accepted as the top one risk factor for POCD, results from studies investigating postoperative cognitive functions in adults have been controversial, and data about the very young adult individuals are lacking.
The present study investigated the spatial reference memory, IL-1β, IL-6, and microglia activation changes in the hippocampus in 2-month-old mice after anesthesia and surgery.
We found that hippocampal IL-1β and IL-6 increased at 6 hours after surgery.
Microglia were profoundly activated in the hippocampus 6 to 24 hours after surgery.
However, no significant behavior changes were found in these mice.
These results indicate that although anesthesia and surgery led to neuroinflammation, the latter was insufficient to impair the spatial reference memory of young adult mice.
American Psychological Association (APA)
Zhao, Yanhua& Huang, Lili& Xu, Huan& Wu, Guangxi& Zhu, Mengyi& Tian, Jie…[et al.]. 2016. Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111007
Modern Language Association (MLA)
Zhao, Yanhua…[et al.]. Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice. Mediators of Inflammation No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1111007
American Medical Association (AMA)
Zhao, Yanhua& Huang, Lili& Xu, Huan& Wu, Guangxi& Zhu, Mengyi& Tian, Jie…[et al.]. Neuroinflammation Induced by Surgery Does Not Impair the Reference Memory of Young Adult Mice. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1111007
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111007