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Regulatory T Cell Induced by Poria cocos Bark Exert Therapeutic Effects in Murine Models of Atopic Dermatitis and Food Allergy
Joint Authors
Shon, Dong-Hwa
See, Hye-Jeong
Choi, Gyeyoung
Kang, Chang-Yuil
Bae, Min-Jung
Shin, Hee Soon
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-29
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The prevalence of allergic disorders including atopic dermatitis (AD) and food allergy (FA) has increased dramatically in pediatric populations, but there is no effective drug available for their management.
Therefore, trials are required for the development of safe therapeutic agents such as herbal medicines.
We determined whether orally administered Poria cocos bark (PCB) extract could exert immunosuppressive effects on allergic and inflammatory symptoms of AD and FA.
For both AD, which was induced using house dust mite extract, and FA, which was induced by exposure to ovalbumin, model mice were orally treated with PCB extract for 62 days and 18 days, respectively.
We also investigated the inductive effect of PCB extract on the generation and maintenance of Foxp3+CD4+ regulatory T cells (Tregs).
The symptoms of AD and FA were ameliorated by the administration of PCB extract.
Furthermore, PCB extract inhibited the Th2-related cytokines and increased the population of Foxp3+CD4+ Tregs in both AD and FA models.
In ex vivo experiments, PCB extract promoted the functional differentiation of Foxp3+CD4+ Tregs, which is dependent on aryl hydrocarbon receptor activation.
Thus, PCB extract has potential as an oral immune suppressor for the treatment of AD and FA through the generation of Tregs.
American Psychological Association (APA)
Bae, Min-Jung& See, Hye-Jeong& Choi, Gyeyoung& Kang, Chang-Yuil& Shon, Dong-Hwa& Shin, Hee Soon. 2016. Regulatory T Cell Induced by Poria cocos Bark Exert Therapeutic Effects in Murine Models of Atopic Dermatitis and Food Allergy. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1111010
Modern Language Association (MLA)
Bae, Min-Jung…[et al.]. Regulatory T Cell Induced by Poria cocos Bark Exert Therapeutic Effects in Murine Models of Atopic Dermatitis and Food Allergy. Mediators of Inflammation No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1111010
American Medical Association (AMA)
Bae, Min-Jung& See, Hye-Jeong& Choi, Gyeyoung& Kang, Chang-Yuil& Shon, Dong-Hwa& Shin, Hee Soon. Regulatory T Cell Induced by Poria cocos Bark Exert Therapeutic Effects in Murine Models of Atopic Dermatitis and Food Allergy. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1111010
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111010