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Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease
Joint Authors
Selvarajah, Senthooran
Todd, Ian
Tighe, Patrick J.
Harrison, Tim
Fairclough, Lucy C.
John, Michelle
Bolton, Charlotte E.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal.
To investigate this, we developed a protein microarray system to detect multiple cytokines in small volumes of serum.
Fourteen cytokines were measured in serum from never-smokers, ex-smokers, current smokers, and COPD patients (GOLD stages 1–3).
Certain individual circulating cytokines (particularly TNFα and IL-1β) were significantly elevated in concentration in the serum of particular COPD patients (and some current/ex-smokers without COPD) and may serve as markers of particularly significant systemic inflammation.
However, numerous circulating cytokines were raised such that their combined, but not individual, elevation was significantly associated with severity of disease, and these may be further indicators of, and contributors to, the systemic inflammatory manifestations of COPD.
The coelevation of numerous circulating cytokines in COPD is consistent with the insidious development, chronic nature, and systemic comorbidities of the disease.
American Psychological Association (APA)
Selvarajah, Senthooran& Todd, Ian& Tighe, Patrick J.& John, Michelle& Bolton, Charlotte E.& Harrison, Tim…[et al.]. 2016. Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111020
Modern Language Association (MLA)
Selvarajah, Senthooran…[et al.]. Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease. Mediators of Inflammation No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1111020
American Medical Association (AMA)
Selvarajah, Senthooran& Todd, Ian& Tighe, Patrick J.& John, Michelle& Bolton, Charlotte E.& Harrison, Tim…[et al.]. Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111020
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111020