Insulin Resistance and Endothelial Dysfunction Constitute a Common Therapeutic Target in Cardiometabolic Disorders

Joint Authors

Janus, A.
Szahidewicz-Krupska, E.
Mazur, G.
Doroszko, A.

Source

Mediators of Inflammation

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-06-20

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Diseases

Abstract EN

Insulin resistance and other risk factors for atherosclerosis, such as hypertension and hypercholesterolemia, promote endothelial dysfunction and lead to development of metabolic syndrome which constitutes an introduction to cardiovascular disease.

The insulin resistance and endothelial dysfunction cross talk between each other by numerous metabolic pathways.

Hence, targeting one of these pathologies with pleiotropic treatment exerts beneficial effect on another one.

Combined and expletive treatment of hypertension, lipid disorders, and insulin resistance with nonpharmacological interventions and conventional pharmacotherapy may inhibit the transformation of metabolic disturbances to fully developed cardiovascular disease.

This paper summarises the common therapeutic targets for insulin resistance, endothelial dysfunction, and vascular inflammatory reaction at molecular level and analyses the potential pleiotropic effects of drugs used currently in management of cardiovascular disease, metabolic syndrome, and diabetes.

American Psychological Association (APA)

Janus, A.& Szahidewicz-Krupska, E.& Mazur, G.& Doroszko, A.. 2016. Insulin Resistance and Endothelial Dysfunction Constitute a Common Therapeutic Target in Cardiometabolic Disorders. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111023

Modern Language Association (MLA)

Janus, A.…[et al.]. Insulin Resistance and Endothelial Dysfunction Constitute a Common Therapeutic Target in Cardiometabolic Disorders. Mediators of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1111023

American Medical Association (AMA)

Janus, A.& Szahidewicz-Krupska, E.& Mazur, G.& Doroszko, A.. Insulin Resistance and Endothelial Dysfunction Constitute a Common Therapeutic Target in Cardiometabolic Disorders. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1111023

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1111023