Vaginal Lactoferrin Modulates PGE2, MMP-9, MMP-2, and TIMP-1 Amniotic Fluid Concentrations
Joint Authors
Contini, Carlo
Gonelli, Arianna
Trentini, Alessandro
Manfrinato, Maria Cristina
Volta, Carlo Alberto
Dallocchio, Franco
Bellini, Tiziana
Maritati, Martina
Vesce, Fortunato
Greco, Pantaleo
Cervellati, Carlo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Inflammation plays an important role in pregnancy, and cytokine and matrix metalloproteases (MMPs) imbalance has been associated with premature rupture of membranes and increased risk of preterm delivery.
Previous studies have demonstrated that lactoferrin (LF), an iron-binding protein with anti-inflammatory properties, is able to decrease amniotic fluid (AF) levels of IL-6.
Therefore, we aimed to evaluate the effect of vaginal LF administration on amniotic fluid PGE2 level and MMP-TIMP system in women undergoing genetic amniocentesis.
One hundred and eleven women were randomly divided into controls ( n = 57 ) or treated with LF 4 hours before amniocentesis ( n = 54 ).
Amniotic fluid PGE2, active MMP-9 and MMP-2, and TIMP-1 and TIMP-2 concentrations were determined by commercially available assays and the values were normalized by AF creatinine concentration.
PGE2, active MMP-9, and its inhibitor TIMP-1 were lower in LF-treated group than in controls ( p < 0.01 , p < 0.005 , and p < 0.001 , resp.).
Conversely, active MMP-2 ( p < 0.0001 ) and MMP-2/TIMP-2 molar ratio ( p < 0.001 ) were increased, whilst TIMP-2 was unchanged.
Our data suggest that LF administration is able to modulate the inflammatory response following amniocentesis, which may counteract cytokine and prostanoid imbalance that leads to abortion.
This trial is registered with Clinical Trial number NCT02695563.
American Psychological Association (APA)
Trentini, Alessandro& Maritati, Martina& Cervellati, Carlo& Manfrinato, Maria Cristina& Gonelli, Arianna& Volta, Carlo Alberto…[et al.]. 2016. Vaginal Lactoferrin Modulates PGE2, MMP-9, MMP-2, and TIMP-1 Amniotic Fluid Concentrations. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1111025
Modern Language Association (MLA)
Trentini, Alessandro…[et al.]. Vaginal Lactoferrin Modulates PGE2, MMP-9, MMP-2, and TIMP-1 Amniotic Fluid Concentrations. Mediators of Inflammation No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1111025
American Medical Association (AMA)
Trentini, Alessandro& Maritati, Martina& Cervellati, Carlo& Manfrinato, Maria Cristina& Gonelli, Arianna& Volta, Carlo Alberto…[et al.]. Vaginal Lactoferrin Modulates PGE2, MMP-9, MMP-2, and TIMP-1 Amniotic Fluid Concentrations. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1111025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111025