Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis
Joint Authors
Li, Ruidong
Wang, Yaxin
Ma, Zhijun
Ma, Muyuan
Wang, Di
Xie, Gengchen
Yin, Yuping
Zhang, Peng
Tao, Kaixiong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Sepsis, frequently caused by infection of bacteria, is considered as an uncontrollable systematic inflammation response syndrome (SIRS).
Maresin 1 (Mar1) is a new proresolving mediator with potent anti-inflammatory effect in several animal models.
However, its effect in sepsis is still not investigated.
To address this question, we developed sepsis model in BALB/c mice by cecal ligation and puncture (CLP) with or without Mar1 treatment.
Our data showed that Mar1 markedly improved survival rate and decreased the levels of proinflammatory cytokines in CLP mice such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β).
Furthermore, Mar1 reduced serum level of lipopolysaccharide (LPS) and enhanced the bacteria clearance in mice sepsis model.
Moreover, Mar1 attenuated lung injury and decreased level of alanine transaminase (ALT), aspartate transaminase (AST), creatinine (Cre), and blood urea nitrogen (BUN) in serum in mice after CLP surgery.
Treatment with Mar1 inhibited activation of nuclear factor kappa B (NF-κb) pathway.
In conclusion, Mar1 exhibited protective effect in sepsis by reducing LPS, bacteria burden in serum, inhibiting inflammation response, and improving vital organ function.
The possible mechanism is partly involved in inhibition of NF-κb activation.
American Psychological Association (APA)
Li, Ruidong& Wang, Yaxin& Ma, Zhijun& Ma, Muyuan& Wang, Di& Xie, Gengchen…[et al.]. 2016. Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111034
Modern Language Association (MLA)
Li, Ruidong…[et al.]. Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis. Mediators of Inflammation No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1111034
American Medical Association (AMA)
Li, Ruidong& Wang, Yaxin& Ma, Zhijun& Ma, Muyuan& Wang, Di& Xie, Gengchen…[et al.]. Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1111034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111034