Expression of Interferon Effector Gene SART1 Correlates with Interferon Treatment Response against Hepatitis B Infection
Joint Authors
Li, Yong
Zhu, Chuanlong
Wang, Faxi
Zhu, Tiantian
Li, Jun
Liu, Shufeng
Xiao, Fei
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Interferon-α (IFN-α) has limited response rate in the treatment of chronic hepatitis B (CHB).
The underlying mechanism of differential responsiveness to IFN remains elusive.
It has been recently reported that SART1 mediates antiviral effects of IFN-α in the hepatitis C virus (HCV) cell culture model.
In this study, we investigated the role of SART1 in antiviral activity of IFN-α against hepatitis B virus (HBV) using blood and liver biopsy samples from chronic hepatitis B patients treated with pegylated IFN-α and HepG2 cells transfected with cloned HBV DNA.
We observed that the basal SART1 expression in liver and PBMCs before IFN treatment was significantly higher in responders than in nonresponders.
Furthermore, baseline SART1 expression level positively correlated with the degree of HBV DNA and HBeAg decline after IFN treatment.
Mechanistically, silencing SART1 abrogated the antiviral activity of IFN-α, reduced the expression of IFN-stimulated genes (ISGs) Mx, OAS, and PKR, and attenuated JAK-STAT signaling in HepG2 cells, suggesting that SART1 regulates IFN-mediated antiviral activity through JAK-STAT signaling and ISG expression.
Our study elucidates the important role of SART1 in IFN-mediated anti-HBV response and provides new insights into understanding variation of IFN treatment response in CHB patients.
American Psychological Association (APA)
Li, Yong& Zhu, Chuanlong& Wang, Faxi& Zhu, Tiantian& Li, Jun& Liu, Shufeng…[et al.]. 2016. Expression of Interferon Effector Gene SART1 Correlates with Interferon Treatment Response against Hepatitis B Infection. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111037
Modern Language Association (MLA)
Li, Yong…[et al.]. Expression of Interferon Effector Gene SART1 Correlates with Interferon Treatment Response against Hepatitis B Infection. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111037
American Medical Association (AMA)
Li, Yong& Zhu, Chuanlong& Wang, Faxi& Zhu, Tiantian& Li, Jun& Liu, Shufeng…[et al.]. Expression of Interferon Effector Gene SART1 Correlates with Interferon Treatment Response against Hepatitis B Infection. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111037
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111037