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e-Cadherin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson Disease
Joint Authors
Albi, Elisabetta
Cataldi, Samuela
Ferri, Ivana
Beccari, T.
Codini, Michela
Légeron, François-Pierre
Siccu, Paola
Sidoni, Angelo
Ambesi-Impiombato, Francesco Saverio
Curcio, Francesco
Hunot, Stephane
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Today a large number of studies are focused on clarifying the complexity and diversity of the pathogenetic mechanisms inducing Parkinson disease.
We used 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a neurotoxin that induces Parkinson disease, to evaluate the change of midbrain structure and the behavior of the anti-inflammatory factor e-cadherin, interleukin-6, tyrosine hydroxylase, phosphatase and tensin homolog, and caveolin-1.
The results showed a strong expression of e-cadherin, variation of length and thickness of the heavy neurofilaments, increase of interleukin-6, and reduction of tyrosine hydroxylase known to be expression of dopamine cell loss, reduction of phosphatase and tensin homolog described to impair responses to dopamine, and reduction of caveolin-1 known to be expression of epithelial-mesenchymal transition and fibrosis.
The possibility that the overexpression of the e-cadherin might be implicated in the anti-inflammatory reaction to MPTP treatment by influencing the behavior of the other analyzed molecules is discussed.
American Psychological Association (APA)
Cataldi, Samuela& Codini, Michela& Hunot, Stephane& Légeron, François-Pierre& Ferri, Ivana& Siccu, Paola…[et al.]. 2016. e-Cadherin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson Disease. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1111042
Modern Language Association (MLA)
Cataldi, Samuela…[et al.]. e-Cadherin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson Disease. Mediators of Inflammation No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1111042
American Medical Association (AMA)
Cataldi, Samuela& Codini, Michela& Hunot, Stephane& Légeron, François-Pierre& Ferri, Ivana& Siccu, Paola…[et al.]. e-Cadherin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson Disease. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1111042
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111042